Serial Frozen Fecal Microbiota Transplantation in the Treatment of Chronic Intestinal Pseudo-obstruction: A Preliminary Study

Lili Gu; Chao Ding; Hongliang Tian; Bo Yang; Xuelei Zhang; Yue Hua; Yifan Zhu; Jianfeng Gong; Weiming Zhu; Jieshou Li; Ning Li

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자료유형: 학술저널

저자정보: Lili Gu (Jinling Hospital Nanjing University School of Medicine Nanjing China) Chao Ding (Jinling Hospital Nanjing University School of Medicine Nanjing China) Hongliang Tian (Jinling Hospital Nanjing University School of Medicine Nanjing China) Bo Yang (Jinling Hospital Nanjing University School of Medicine Nanjing China) Xuelei Zhang (Jinling Hospital Nanjing University School of Medicine Nanjing China) Yue Hua (Jinling Hospital Nanjing University School of Medicine Nanjing China) Yifan Zhu (Jinling Hospital Nanjing University School of Medicine Nanjing China) Jianfeng Gong (Jinling Hospital Nanjing University School of Medicine Nanjing China) Weiming Zhu (Jinling Hospital Nanjing University School of Medicine Nanjing China) Jieshou Li (Jinling Hospital Nanjing University School of Medicine Nanjing China) Ning Li (Jinling Hospital Nanjing University School of Medicine Nanjing China)

저널정보: 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.23 No.2

발행연도: 2017.1

수록면: 289 - 297 (9page)

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Background/Aims: Chronic intestinal pseudo-obstruction (CIPO) is a serious, life-threatening motility disorder that is often related to bacterial overgrowth. Fecal microbiota transplantation (FMT) results in restoration of the normal intestinal microbial community structure. We investigatedthe efficacy of FMT in the treatment of CIPO patients. Methods: Nine patients (age 18-53 years) with CIPO were enrolled in this prospective, open-label study. Patients received FMT for 6 consecutivedays through nasojejunal (NJ) tubes and were followed up for 8 weeks after treatment. We evaluated the rate of clinical improvementand remission, feeding tolerance of enteral nutrition, and CT imaging scores of intestinal obstructions. Lactulose hydrogen breathtests were performed before FMT and 8 weeks after FMT to evaluate for the presence small intestinal bacterial overgrowth (SIBO). Results: FMT significantly alleviated bloating symptoms, and symptoms of pain were relieved 2 weeks after FMT. Enteral nutrition administeredthrough a NJ tube after FMT was well-tolerated by 66.7% (6/9) of patients. CT scores of intestinal obstructions were significantlyreduced after FMT (P = 0.014). SIBO was eliminated in 71.0% (5/7) of patients. Conclusions: This pilot study demonstrated the safety of using FMT. FMT may relieve symptoms in selected patients with CIPO. FMT may alsoimprove patient tolerance of enteral nutrition delivered via a NJ tube.

참고문헌 (35)

참고문헌 신청

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Amiot A / 2012 / Prognostic yield of esophageal manometry in chronic intestinal pseudo-obstruction: a retrospective cohort of 116 adult patients / Neurogastroenterol Motil 24:1008~e542

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Gabbard SL / 2013 / Chronic intestinal pseudo-obstruction / Nutr Clin Pract 28:307~316

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