지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.12 No.4
- 발행연도
- 2020.1
- 수록면
- 608 - 625 (18page)
이용수
초록· 키워드
오류제보하기
Purpose: Accumulating evidence has suggested that toll-like receptor 4 (TLR4) is critically involved in the pathogenesis of asthma. The aim of this study was to investigate the role of TLR4 in toluene diisocyanate (TDI)-induced allergic airway inflammation. Methods: TLR4−/− and wild-type (WT) C57BL/10J mice were sensitized and challenged with TDI to generate a TDI-induced asthma model. B-cell lymphoma 2 (Bcl-2) inhibitors, ABT-199 (4 mg/kg) and ABT-737 (4 mg/kg), were intranasally given to TDI-exposed TLR4−/− mice after each challenge. Results: TDI exposure led to increased airway hyperresponsiveness (AHR), granulocyte flux, bronchial epithelial shedding and extensive submucosal collagen deposition, which were unexpectedly aggravated by TLR4 deficiency. Following TDI challenge, TLR4−/− mice exhibited down-regulated interleukin-17A and increased colony-stimulating factor 3 in bronchoalveolar lavage fluid (BALF), while WT mice did not. In addition, TLR4 deficiency robustly suppressed the expression of NOD-like receptor family pyrin domain containing 3 and NLR family CARD domain containing 4, decreased caspase-1 activity in TDI-exposed mice, but had no effect on the level of high mobility group box 1 in BALF. Flow cytometry revealed that TDI hampered both neutrophil and eosinophil apoptosis, of which neutrophil apoptosis was further inhibited in TDI-exposed TLR4−/− mice, with marked up-regulation of Bcl-2. Moreover, inhibition of Bcl-2 with either ABT-199 or ABT-737 significantly alleviated neutrophil recruitment by promoting apoptosis. Conclusions: These data indicated that TLR4 deficiency promoted neutrophil infiltration by impairing its apoptosis via up-regulation of Bcl-2, thereby resulting in deteriorated AHR and airway inflammation, which suggests that TLR4 could be a negative regulator of TDI-induced neutrophilic inflammation.
목차
등록된 정보가 없습니다.
참고문헌 (47)
참고문헌 신청
Masoli M / 2004 / The global burden of asthma: executive summary of the GINA Dissemination Committee report / Allergy 59:469~478
Kim RY / 2017 / Role for NLRP3 inflammasome-mediated, IL-1β-dependent responses in severe, steroid-resistant asthma / Am J Respir Crit Care Med 196:283~297
Zakeri A / 2018 / Dual role of toll-like receptors in human and experimental asthma models / Front Immunol 9:1027
Hammad H / 2009 / House dust mite allergen induces asthma via toll-like receptor 4 triggering of airway structural cells / Nat Med 15:410~416
Tang H / 2019 / TLR4 antagonist ameliorates combined allergic rhinitis and asthma syndrome (CARAS) by reducing inflammatory monocytes infiltration in mice model / Int Immunopharmacol 73:254~260
Kim RY / 2017 / Role for NLRP3 inflammasome-mediated, IL-1β-dependent responses in severe, steroid-resistant asthma / Am J Respir Crit Care Med 196:283~297
Zakeri A / 2018 / Dual role of toll-like receptors in human and experimental asthma models / Front Immunol 9:1027
Hammad H / 2009 / House dust mite allergen induces asthma via toll-like receptor 4 triggering of airway structural cells / Nat Med 15:410~416
Tang H / 2019 / TLR4 antagonist ameliorates combined allergic rhinitis and asthma syndrome (CARAS) by reducing inflammatory monocytes infiltration in mice model / Int Immunopharmacol 73:254~260
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Is TLR4 Critical for Neutrophil Apoptosis in Occupational Asthma?
Allergy, Asthma & Immunology Research
2020 .01
-
TLR10 and Its Unique Anti-Inflammatory Properties and Potential Use as a Target in Therapeutics
Immune Network
2020 .06
-
Involvement of Innate Lymphoid Cells and Dendritic Cells in a Mouse Model of Chemical-induced Asthma
Allergy, Asthma & Immunology Research
2021 .01
-
Serum Periostin Levels: A Potential Serologic Marker for Toluene Diisocyanate-Induced Occupational Asthma
Yonsei Medical Journal
2018 .01
-
Toll-like Receptor 2 in Autoimmune Inflammation
Immune Network
2021 .06
-
Association of Single Nucleotide Polymorphisms in Toll-like Receptor Genes With Asthma Risk: A Systematic Review and Meta-analysis
Allergy, Asthma & Immunology Research
2015 .01
-
Early IL-17A Prevention Rather Than Late IL-17A Neutralization Attenuates Toluene Diisocyanate-Induced Mixed Granulocytic Asthma
Allergy, Asthma & Immunology Research
2022 .09
-
Clinical Significance of Toll-Like Receptor and Toll-Like Receptor Blocker
Urogenital Tract Infection
2016 .01
-
Decreased expression of Toll-like receptor 4 and 5 during progression of prostate transformation in transgenic adenocarcinoma of mouse prostate mice
Journal of Veterinary Science
2015 .09
-
The Roles of the Gut Microbiota and Toll-like Receptors in Obesity and Nonalcoholic Fatty Liver Disease
Journal of Obesity & Metabolic Syndrome
2017 .01
-
Comparison of fertility competence in toll-like receptor 4 (TLR4)-knock out male mice fed a high-fat diet
Journal of Biomedical and Translational Research
2023 .06
-
Toll-like receptor 2 promotes neurogenesis from the dentate gyrus after photothrombotic cerebral ischemia in mice
The Korean Journal of Physiology & Pharmacology
2018 .03
-
Variable localization of Toll-like receptors in human fallopian tube epithelial cells
Clinical and experimental reproductive medicine : CERM
2018 .01
-
Association with Genetic Polymorphism of rs117033348 and Allergic Disease in Korean Population
대한의생명과학회지
2021 .09
-
Toll-Like Receptor Gene Expression during Trichinella spiralis Infection
Parasites, Hosts and Diseases
2015 .08
-
Sex hormones alter the response of Toll-like receptor 3 to its specific ligand in fallopian tube epithelial cells
Clinical and experimental reproductive medicine : CERM
2018 .01
-
Pristimerin Inhibits Inducible Nitric Oxide Synthase Expression Induced by TLR Agonists
대한의생명과학회지
2019 .03
-
Dehydrocostus Lactone Suppresses the Expression of iNOS Induced by TLR Agonists
대한의생명과학회지
2019 .09
-
Occupational toluene diisocyanates exposure and cancer mortality : 12-year follow-up study for ten thousand male workers in Korea
대한직업환경의학회 학술대회 논문집
2017 .11
-
Two Sjogren syndrome-associated oral bacteria, Prevotella melaninogenica and Rothia mucilaginosa, induce the upregulation of major histocompatibility complex class I and hypoxia-associated cell death, respectively, in human salivary gland cells
International Journal of Oral Biology
2021 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0