지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.4
- 수록면
- 116 - 125 (10page)
- DOI
- 10.4078/jrd.2023.0005
이용수
초록· 키워드
오류제보하기
Objective: The aim of the study was to investigate the association between the levels of leptin in the circulating of individuals with rheumatoid arthritis (RA) and the severity of the disease.
Methods: We looked through the databases of Embase, Medline, and the Cochrane Library. We conducted a meta-analysis on the correlations between circulating leptin and the Disease Activity Score 28-erythrocyte sedimentation rate (DAS28-ESR) and Creactive protein (CRP) levels in RA patients, as well as a meta-analysis of circulating or circulating leptin levels in RA patients.
Results: This meta-analysis study analyzed 42 different comparisons from 37 different publications, including a total of 2,350 patients with RA and 1,815 controls. The RA group had substantially higher leptin levels than the control group (standardized mean difference [SMD]=0.507, 95% confidence interval [CI]=0.309~0.704, p<0.001). The finding that RA patients had higher leptin levels was unaffected by sample size. The correlation between circulating leptin levels and DAS28 is statistically significant (correlation coefficient=0.247, 95% CI=0.087~0.396, p=0.003). Leptin levels are also correlated with CRP levels (correlation coefficient= 0.203, 95% CI=0.048~0.349, p=0.010).
Conclusion: This comprehensive meta-analysis demonstrates that the circulating leptin levels of RA patients are elevated, and provides compelling evidence of the significant relationship between leptin levels and the activity of RA. The findings of this research suggest that leptin plays a significant role in the pathophysiology of this disease.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Circulating Interleukin-37 Levels in Rheumatoid Arthritis and Systemic Lupus Erythematosus and Their Correlations With Disease Activity: A Meta-analysis
대한류마티스학회지
2020 .01
-
YKL-40 Levels in Rheumatoid Arthritis and Their Correlation with Disease Activity: A Meta-analysis
대한류마티스학회지
2019 .01
-
Rheumatoid arthritis in tight disease control is no longer risk of bone mineral density loss
Osteoporosis and Sarcopenia
2020 .01
-
Association between the Neutrophil-to-lymphocyte Ratio, and Platelet-to-lymphocyte Ratio and Rheumatoid Arthritis and their Correlations with the Disease Activity: A Meta-analysis
대한류마티스학회지
2018 .01
-
Mortality in Korean Patients With Rheumatoid Arthritis
대한류마티스학회지
2021 .01
-
Clinical Significance of Elevated Serum Immunoglobulin G4 Levels in Patients With Rheumatoid Arthritis
대한류마티스학회지
2020 .01
-
Characteristics of Appendicular Tissue Components in Patients with Rheumatoid Arthritis
대한골대사학회지
2020 .01
-
Clinical and immunological responses to COVID-19 vaccination in rheumatoid arthritis patients on disease modifying antirheumatic drugs: a cross-sectional study
대한류마티스학회지
2024 .01
-
Associations of periodontal status in periodontitis and rheumatoid arthritis patients
Journal of Periodontal & Implant Science
2021 .01
-
Comparison of Disease Activity Score 28 Using C-reactive Protein and Disease Activity Score 28 Using Erythrocyte Sedimentation Rate in Assessing Activity and Treatment Response in Rheumatoid Arthritis: A Meta-analysis
대한류마티스학회지
2016 .01
-
Relationship between Metabolic Syndrome and Rheumatoid Arthritis
Korean Journal of Family Medicine
2016 .01
-
Hypereosinophilic Syndrome Associated with the Onset of Rheumatoid Arthritis: A Case Report
대한류마티스학회지
2017 .01
-
Disease Characteristics and Change in Arthritis Activity according to Treatment in Hepatitis B Surface Antigen-positive Rheumatoid Arthritis Patients: a Retrospective Chart Review Study
Journal of Korean Medical Science
2018 .01
-
Lessons From the Success and Failure of Targeted Drugs for Rheumatoid Arthritis: Perspectives for Effective Basic and Translational Research
Immune Network
2022 .02
-
Risk Factors for the Development and Progression of Atlantoaxial Subluxation in Surgically Treated Rheumatoid Arthritis Patients, Considering the Time Interval between Rheumatoid Arthritis Diagnosis and Surgery
대한신경외과학회지
2016 .01
-
Height Restoration after Balloon Kyphoplasty in Rheumatoid Patients with Osteoporotic Vertebral Compression Fracture
Asian Spine Journal
2015 .01
-
류마티스관절염 치료지침 업데이트
대한내과학회지
2022 .04
-
Proteomics in Rheumatoid Arthritis Research
Immune Network
2015 .08
-
Productivity Loss of Rheumatoid Arthritis Patients according to the Their Stages of the Disease Activity Score
대한류마티스학회지
2018 .01
-
Adult Stem Cell Treatment for Rheumatoid Arthritis
대한류마티스학회지
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0