지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 983 - 991 (9page)
이용수
초록· 키워드
오류제보하기
Background Hyperhomocysteinemia is a potential risk factor for the development of metabolic syndrome (MetS). Among genes involved in homocysteine metabolism, polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene are known to be associated with MetS incidence. However, effects of polymorphisms of other folate metabolism-related genes on MetS susceptibility are not well known yet. Objective This study was to determine whether methionine synthase (MTR) 2756A > G, methionine synthase reductase (MTRR ) 66A > G, and thymidylate synthase enhancer region (TSER) 2R/3R polymorphisms might be associated with risks of MetS development in the Korean population. Methods Genotype analysis of the three polymorphisms was performed for a total of 483 subjects including 236 MetS patients and 247 unrelated healthy controls using polymerase chain reaction-restriction fragment length polymorphism technique. Results The present study revealed that MTRR and TSER polymorphisms were associated with susceptibility to MetS. Several genotypes and allele combinations from the three polymorphisms were also related to the MetS prevalence. When polymorphism data were stratified according to the risk components of MetS, MTR polymorphism was significantly associated with an increased risk of MetS in subjects with systolic blood pressure < 132.7 mmHg (AOR 1.842, 95% CI 1.039–3.266, P = 0.037) and fasting blood glucose level < 106.3 mg/dL (AOR 1.772, 95% CI 1.069–2.937, P = 0.027). MTRR polymorphism was significantly associated with a decreased risk of MetS in subjects with triglyceride level < 216.3 mg/dL (AOR 0.616, 95% CI 0.399–0.951, P = 0.029). To the best of our knowledge, this is the first to provide reliable evidence about the association of other folate metabolism-related gene polymorphisms besides MTHFR with MetS susceptibility and its risk factors. Conclusion Results of this study suggest that MTRR and TSER polymorphisms might be potential genetic markers for the risk of MetS development in Korean population.
목차
등록된 정보가 없습니다.
참고문헌 (49)
참고문헌 신청
Anwar W / 2001 / Hyperhomocysteinemia is related to residual glomerular filtration and folate, but not to methylenetetrahydrofolate-reductase and methionine synthase polymorphisms, in supplemented end-stage renal disease patients undergoing hemodialysis / Clin Chem Lab Med 39:747~752
Bjorck J / 2006 / Associations between serum insulin and homocysteine in a Swedish population-A potential link between the metabolic syndrome and hyperhomocysteinemia : the Skaraborg project / Metabolism 55:1007~1013
Blom HJ / 2011 / Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects / J Inherit Metab Dis 34:75~81
Chaabane S / 2018 / Association of hyperhomocysteinemia with genetic variants in key enzymes of homocysteine metabolism and methotrexate toxicity in rheumatoid arthritis patients / Inflamm Res 67:703~710
Chen J / 2001 / Influence of a methionine synthase(D919G)polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction / Atherosclerosis 154:667~672
Bjorck J / 2006 / Associations between serum insulin and homocysteine in a Swedish population-A potential link between the metabolic syndrome and hyperhomocysteinemia : the Skaraborg project / Metabolism 55:1007~1013
Blom HJ / 2011 / Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects / J Inherit Metab Dis 34:75~81
Chaabane S / 2018 / Association of hyperhomocysteinemia with genetic variants in key enzymes of homocysteine metabolism and methotrexate toxicity in rheumatoid arthritis patients / Inflamm Res 67:703~710
Chen J / 2001 / Influence of a methionine synthase(D919G)polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction / Atherosclerosis 154:667~672
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effects of methionine synthase and methionine synthase reductase polymorphisms on hypertension susceptibility
Genes & Genomics
2020 .01
-
Tuberculosis risk is associated with genetic polymorphisms in the LRP2, CUBN, and VDR genes
Genes & Genomics
2020 .01
-
Prognostic significance of three endothelial nitric oxide synthase (eNOS) polymorphisms and metabolic syndrome (MetS) in patients with colorectal cancer
Genes & Genomics
2022 .06
-
The Apolipoprotein A1 polymorphisms were associated with decreased risk for metabolic syndrome in Koreans
Genes & Genomics
2015 .01
-
일부 초등학생의 대표적 신체활동의 에너지소비량 측정 및 에너지소비량과 체중과의 상관성 분석
Journal of Nutrition and Health
2015 .04
-
Folate metabolizing gene polymorphisms and genetic vulnerability to preterm birth in Korean women
Genes & Genomics
2021 .08
-
Association of COX2 −765G>C promoter polymorphism and coronary artery disease in Korean population
Genes & Genomics
2019 .01
-
Methylenetetrahydrofolate reductase, MTHFR, polymorphisms and predisposition to different multifactorial disorders
Genes & Genomics
2017 .01
-
Association study of the three functional polymorphisms (TAS2R46G>A, OR4C16G>A, and OR4X1A>T) with recurrent pregnancy loss
Genes & Genomics
2019 .01
-
남성 대사증후군 유병률과 관련 요인 분석: 흡연 상태와 신체활동
Korean Journal of Health Promotion
2023 .06
-
Whole genome detection of recent selection signatures in Sarabi cattle: a unique Iranian taurine breed
Genes & Genomics
2020 .01
-
Inverse association of improved adherence to dietary guidelines with metabolic syndrome: the Seoul Metabolic Syndrome Management program
Nutrition Research and Practice
2020 .12
-
Inverse association of improved adherence to dietary guidelines with metabolic syndrome: the Seoul Metabolic Syndrome Management program
Nutrition Research and Practice
2020 .12
-
Gender-specific association of polymorphisms in the 50-UTR and 30-UTR of VEGF gene with hypertensive patients
Genes & Genomics
2015 .01
-
Leptin and uric acid as predictors of metabolic syndrome in jordanian adults
Nutrition Research and Practice
2016 .08
-
Leptin and uric acid as predictors of metabolic syndrome in jordanian adults
Nutrition Research and Practice
2016 .08
-
Transethnic meta-analysis of exome-wide variants identifies new loci associated with male-specific metabolic syndrome
Genes & Genomics
2022 .05
-
Frequency of steamed food consumption and risk of metabolic syndrome in Korean females: data from Korean Genome and Epidemiology Study
Journal of Nutrition and Health
2022 .04
-
Association of glutathione S-transferase M1 and T1 null/present polymorphism with physical performance in the Korean population
Genes & Genomics
2019 .01
-
Development of a Metabolic Syndrome Classification and Prediction Model for Koreans Using Deep Learning Technology: The Korea National Health and Nutrition Examination Survey (KNHANES) (2013–2018)
Clinical Nutrition Research
2023 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0