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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 106 - 113 (8page)
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Background: Low 25-hydroxyvitamin D (25OHD) levels are associated with the incidence of type 2 diabetes mellitus (T2DM). However, the association between 25OHD and metabolic health status or diabetic complications is inconclusive. We evaluated this relationship between vitamin D status and metabolic parameters and complications of T2DM. Methods: This study included 1,392 patients with T2DM who visited Eulji and Ewha Diabetes Center between January 2011 and August 2016. Anthropometric parameters and laboratory tests including glycated hemoglobin (HbA1c), lipid profile, liver and kidney function, and urinary albumin-to-creatinine ratio (UACR) were evaluated. Diabetic macro- and microvascular complications were determined through a medical record review. Serum 25OHD concentrations were measured by chemiluminescent immunoassay. Results: The mean 25OHD level was 16.8±9.6 ng/mL. Vitamin D deficiency (<20 ng/mL) and severe deficiency (<10 ng/mL) were observed in 990 (71.1%) and 351 (25.2%) participants, respectively. 25OHD level was positively correlated with age and highdensity lipoprotein cholesterol (HDL-C) level and negatively correlated with HbA1c, triglyceride level, and UACR. HDL-C and UACR were significantly associated with 25OHD after adjusting for other variables. Vitamin D deficiency was independently related to nephropathy after adjusting for confounding variables. Conclusion: Vitamin D deficiency was common among Korean T2DM patients; it was independently associated with microalbuminuria and HDL level, and positively related to diabetic nephropathy.
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참고문헌 (38)
참고문헌 신청
Chen L / 2011 / The worldwide epidemiology of type 2 diabetes mellitus : present and future perspectives / Nat Rev Endocrinol 8:228~236
Kannel WB / 1979 / Diabetes and cardiovascular risk factors : the Framingham study / Circulation 59:8~13
Thacher TD / 2011 / Vitamin D insufficiency / Mayo Clin Proc 86:50~60
Pittas AG / 2007 / The role of vitamin D and calcium in type 2 diabetes. A systematic review y and meta-analysis / J Clin Endocrinol Metab 92:2017~2029
Scragg R / 2004 / Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey / Diabetes Care 27:2813~2818
Kannel WB / 1979 / Diabetes and cardiovascular risk factors : the Framingham study / Circulation 59:8~13
Thacher TD / 2011 / Vitamin D insufficiency / Mayo Clin Proc 86:50~60
Pittas AG / 2007 / The role of vitamin D and calcium in type 2 diabetes. A systematic review y and meta-analysis / J Clin Endocrinol Metab 92:2017~2029
Scragg R / 2004 / Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey / Diabetes Care 27:2813~2818
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