지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 244 - 250 (7page)
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초록· 키워드
오류제보하기
Purpose: To investigate the changes in testosterone levels and rates of chemical castration following androgen-deprivation therapy (ADT) with goserelin, triptorelin, and leuprolide. Materials and Methods: We retrospectively reviewed the medical records of 125 patients with prostate cancer treated with luteinizing hormone-releasing hormone (LHRH) agonists between January 2009 and December 2015. Changes in testosterone concentration during 9 months of ADT with goserelin 11.34 mg, triptorelin 11.25 mg, and leuprolide 11.25 mg were analyzed using a mixed model. The number of patients with serum testosterone below castration levels defined as various values (<50 ng/dL, <20 ng/dL, or <10 ng/dL) at 3, 6, and 9 months were also evaluated. Results: Of the 125 patients, 59 received goserelin, 44 received triptorelin, and 22 received leuprolide, respectively. The lowest mean testosterone levels during 9 months of treatment were achieved in patients treated with triptorelin, followed by those treated with leuprolide, and then by those treated with goserelin (p=0.001). Significant differences in chemical castration levels were observed only at <10 ng/dL, with 54.2% of goserelin, 93.2% of triptorelin, and 86.4% of leuprolide treated patients (p<0.001). Conclusions: Three LHRH agonists showed comparable efficacy for achieving castration when the castration threshold was 50 or 20 ng/dL. However, triptorelin was the most potent LHRH agonist, achieving the lowest mean testosterone levels and the highest rate of chemical castration at <10 ng/dL testosterone.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Denis L / 1993 / Overview of phase III trials on combined androgen treatment in patients with metastatic prostate cancer / Cancer 72(12 Suppl):3888~3895
Seidenfeld J / 2000 / Single-therapy androgen suppression in men with advanced prostate cancer : a systematic review and meta-analysis / Ann Intern Med 132:566~577
Dias Silva É / 2012 / Goserelin versus leuprolide in the chemical castration of patients with prostate cancer / Int Urol Nephrol 44:1039~1044
Schally AV / 1971 / Gonadotropin-releasing hormone : one polypeptide regulates secretion of luteinizing and follicle-stimulating hormones / Science 173:1036~1038
Kiesel L / 1993 / Molecular mechanisms of gonadotrophin releasing hormone-stimulated gonadotrophin secretion / Hum Reprod 8(Suppl 2):23~28
Seidenfeld J / 2000 / Single-therapy androgen suppression in men with advanced prostate cancer : a systematic review and meta-analysis / Ann Intern Med 132:566~577
Dias Silva É / 2012 / Goserelin versus leuprolide in the chemical castration of patients with prostate cancer / Int Urol Nephrol 44:1039~1044
Schally AV / 1971 / Gonadotropin-releasing hormone : one polypeptide regulates secretion of luteinizing and follicle-stimulating hormones / Science 173:1036~1038
Kiesel L / 1993 / Molecular mechanisms of gonadotrophin releasing hormone-stimulated gonadotrophin secretion / Hum Reprod 8(Suppl 2):23~28
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