지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 34 - 44 (11page)
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초록· 키워드
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The inflammatory bowel diseases (IBD), which consist of Crohn’s disease and ulcerative colitis, are chronic, incurable immune-mediated inflammatory disorders of the intestine. As IBD incidence continues to increase globally and its mortality is low, prevalent cases of IBD are rapidly increasing, thereby leading to a substantial increase in health care costs. Although the introduction of biologic agents for IBD management has revolutionized the armamentarium of IBD therapy, the high cost of this therapy is concerning. With the expirations of patents for existing biologic agents (originals), biosimilars with cheaper costs have been highlighted in the field of IBD. Despite concerns regarding their short- and long-term efficacy, safety, immunogenicity, and interchangeability, increasing evidence via prospective observations and phase III or IV clinical trials, which aim to prove the “biosimilarity” of biosimilars to originals, has partly confirmed their efficacy, safety, and interchangeability. Additionally, although patients and physicians are reluctant to use biosimilars, a positive budget impact has been reported owing to their use in different countries. In the near future, multiple biosimilars with lower costs, and efficacy and safety profile similar to originals, could be used to treat IBD; thus, further consideration and knowledge dissemination are warranted in this new era of biosimilars.
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참고문헌 (66)
참고문헌 신청
Rungoe C / 2014 / Changes in medical treatment and surgery rates in inflammatory bowel disease : a nationwide cohort study 1979-2011 / Gut 63:1607~1616
Park SH / 2014 / Long-term prognosis of Crohn’s disease and its temporal change between 1981 and 2012 : a hospital-based cohort study from Korea / Inflamm Bowel Dis 20:488~494
Lee HS / 2015 / Long-term prognosis of ulcerative colitis and its temporal change between 1977 and 2013 : a hospital-based cohort study from Korea / J Crohns Colitis 9:147~155
Aniwan S / 2017 / Epidemiology, natural history, and risk stratification of Crohn’s disease / Gastroenterol Clin North Am 46:463~480
Molodecky NA / 2012 / Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review / Gastroenterology 142:46~54
Park SH / 2014 / Long-term prognosis of Crohn’s disease and its temporal change between 1981 and 2012 : a hospital-based cohort study from Korea / Inflamm Bowel Dis 20:488~494
Lee HS / 2015 / Long-term prognosis of ulcerative colitis and its temporal change between 1977 and 2013 : a hospital-based cohort study from Korea / J Crohns Colitis 9:147~155
Aniwan S / 2017 / Epidemiology, natural history, and risk stratification of Crohn’s disease / Gastroenterol Clin North Am 46:463~480
Molodecky NA / 2012 / Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review / Gastroenterology 142:46~54
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