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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 128 - 134 (7page)
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Background/Aims: Lenvatinib was recently proven to be non-inferior to sorafenib in treating unresectable hepatocellular carcinoma (HCC) in a phase-3 randomized controlled trial. In this study, we investigated whether the response to lenvatinib was affected by tumor immunogenicity. Methods: Between May 2019 and April 2020, nine patients with intermediate-to-advanced HCC, who were treated with lenvatinib after liver biopsy, were enrolled. Immunohistochemical staining and multi-color flow cytometry were performed on specimens obtained from liver biopsy. Results: Among the nine patients enrolled, four showed objective responses (complete responses+partial responses). Immunohistochemical staining for CD3, CD68, and programmed cell death ligand 1 (PD-L1) demonstrated that patients with objective responses showed marked infiltration of T cells and PD-L1-expressing macrophages in intra-tumoral and peri-tumoral tissues compared to those without objective responses. A significant difference in the numbers of infiltrated T cells, both in the intra-tumoral (P<0.01) and peri-tumoral regions (P<0.05), were identified between responders and non-responders. Regarding the number of infiltrated macrophages, no significant difference was found between the responders and non-responders, although the number of PD-L1-expressing tumor-associated macrophages was significantly higher in responders than that in non-responders (P<0.05). Conclusions: Tumor immunogenicity, as indicated by T cell and PD-L1-positive macrophage infiltration, affects lenvatinib response in unresectable HCC.
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참고문헌 (27)
참고문헌 신청
Yoon SK / 2018 / Molecular mechanism of hepatocellular carcinoma / Hepatoma Research 4:42
Dika IE / 2017 / Treatment options after sorafenib failure in patients with hepatocellular carcinoma / Clin Mol Hepatol 23:273~279
Sung PS / 2018 / (18)F-fluorodeoxyglucose uptake of hepatocellular carcinoma as a prognostic predictor in patients with sorafenib treatment / Eur J Nucl Med Mol Imaging 45:384~391
Bangaru S / 2020 / Review article : new therapeutic interventions for advanced hepatocellular carcinoma / Aliment Pharmacol Ther 51:78~89
Kudo M / 2018 / Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 noninferiority tria / The Lancet 391:1163~1173
Dika IE / 2017 / Treatment options after sorafenib failure in patients with hepatocellular carcinoma / Clin Mol Hepatol 23:273~279
Sung PS / 2018 / (18)F-fluorodeoxyglucose uptake of hepatocellular carcinoma as a prognostic predictor in patients with sorafenib treatment / Eur J Nucl Med Mol Imaging 45:384~391
Bangaru S / 2020 / Review article : new therapeutic interventions for advanced hepatocellular carcinoma / Aliment Pharmacol Ther 51:78~89
Kudo M / 2018 / Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 noninferiority tria / The Lancet 391:1163~1173
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