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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한미용성형외과학회 Archives of Aesthetic Plastic Surgery Archives of Aesthetic Plastic Surgery Vol.22 No.1
- 발행연도
- 2016.1
- 수록면
- 35 - 39 (5page)
이용수
이 논문의 연구 히스토리 (2)
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초록· 키워드
오류제보하기
Keloids are abnormal wound responses that are caused by hyperproliferative growth of connective tissue during the healing process. Recent research findings introduced the roles of reactive oxygen species (ROS) in the process of keloid formation. ROS induces oxidative stress and promotes the activities of oxidative damage-inducible genes. Aldo-keto reductase 1C3 (AKR1C3) prevents destructive ROS toxicity by detoxification of reactive carbonyl species. Thus, this study aimed to compare the expression of AKR1C3 in both normal and keloid skin in vivo. Six specimens of normal skin and six specimens of keloid tissues from human subjects were used to evaluate the expression of AKR1C3 by immunofluorescent staining of tissues and western blotting. By western blotting, it was confirmed that the amount of AKR1C3 protein is significantly reduced in keloid tissues compared to normal tissues. Weak expression of AKR1C3 was also found in keloid tissues by immunofluorescent staining. This study confirmed that the expression of AKR1C3 protein participates in ROS metabolism and plays a part in the downregulation of human keloid formation. To the best of our knowledge, this is the first work that reveals that AKR1C3 can affect the formation of keloids.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Ehrlich HP / 1994 / Morphological and immunochemical differences between keloid and hypertrophic scar / Am J Pathol 145:105~113
Lee YJ / 2011 / Cadmium-induced up-regulation of aldo-keto reductase 1C3 expression in human nasal septum carcinoma RPMI-2650 cells: involvement of reactive oxygen species and phosphatidylinositol 3-kinase/Akt / Environ Toxicol Pharmacol 31:469~478
De Felice B / 2009 / Differential apoptosis markers in human keloids and hypertrophic scars fibroblasts / Mol Cell Biochem 327:191~201
Alhady SM / 1969 / Keloids in various races. A review of 175 cases / Plast Reconstr Surg 44:564~566
Dröge W / 1994 / Functions of glutathione and glutathione disulfide in immunology and immunopathology / FASEB J 8:1131~1138
Lee YJ / 2011 / Cadmium-induced up-regulation of aldo-keto reductase 1C3 expression in human nasal septum carcinoma RPMI-2650 cells: involvement of reactive oxygen species and phosphatidylinositol 3-kinase/Akt / Environ Toxicol Pharmacol 31:469~478
De Felice B / 2009 / Differential apoptosis markers in human keloids and hypertrophic scars fibroblasts / Mol Cell Biochem 327:191~201
Alhady SM / 1969 / Keloids in various races. A review of 175 cases / Plast Reconstr Surg 44:564~566
Dröge W / 1994 / Functions of glutathione and glutathione disulfide in immunology and immunopathology / FASEB J 8:1131~1138
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
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