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학술저널
저자정보
Abdolrahim Ahmadi (Tarbiat Modarres University) Saeid Kaviani (Tarbiat Modarres University) Marjan Yaghmaie (Tehran University of Medical Sciences) Hossein Pashaiefar (Tehran University of Medical Sciences) Mohammad Ahmadvand (Tehran University of Medical Sciences) Mahdi Jalili (Tehran University of Medical Sciences) Kamran Alimoghaddam (Tehran University of Medical Sciences) Mohammad Eslamijouybari (Mazandaran University of Medical Science) Ardeshir Ghavamzadeh (Tehran University of Medical Sciences)
저널정보
대한혈액학회 Blood Research Blood Research Vol.53 No.4
발행연도
2018.1
수록면
320 - 324 (5page)

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BackgroundRecent studies have devoted much attention to non-protein-coding transcripts in relation to a wide range of malignancies. MALAT1, a long non-coding RNA, has been reported to be associated with cancer progression and prognosis. Thus, we here determined MALAT1 gene expression in chronic lymphocytic leukemia (CLL), a genetically heteroge-neous disease, and explored its possible relationships with cytogenetic abnormalities.MethodsMALAT1 expression level was evaluated using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) on blood mononuclear cells from 30 non-treated CLL patients and 30 matched healthy controls. Cytogenetic abnormalities were de-termined in patients by fluorescence in situ hybridization (FISH).ResultsMALAT1 expression level was up-regulated in the CLL group compared to healthy controls (P=0.008). Del13q14, followed by Del11q22, were the most prevalent cytogenetic abnormalities. We found no association between the FISH results and MALAT1 ex-pression in patients.ConclusionAltered expression of MALAT1 is associated with CLL development. Further investigations are required to assess the relationship between this long non-coding RNA and CLL patient survival and prognosis.

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