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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
Yanwen Chen (Department of Gastroenterology Peking Union Medical College Hospital Chinese Academy of Medical Sci) Ruifeng Wang (Department of Gastroenterology Peking Union Medical College Hospital Chinese Academy of Medical Sci) Bo Hou (Department of RadiologyPeking Union Medical College Hospital Chinese Academy of Medical Sciences Be) Feng Feng (Department of RadiologyPeking Union Medical College Hospital Chinese Academy of Medical Sciences Be) Xiucai Fang (Department of Gastroenterology Peking Union Medical College Hospital Chinese Academy of Medical Sci) Liming Zhu (Department of Gastroenterology Peking Union Medical College Hospital Chinese Academy of Medical Sci) Xiaohong Sun (Department of Gastroenterology Peking Union Medical College Hospital Chinese Academy of Medical Sci) Zhifeng Wang (Department of Gastroenterology Peking Union Medical College Hospital Chinese Academy of Medical Sci) Meiyun Ke (Department of Gastroenterology Peking Union Medical College Hospital Chinese Academy of Medical Sci)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.24 No.2
발행연도
2018.1
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268 - 279 (12page)

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Background/Aims Functional dyspepsia (FD) remains a great clinical challenge since the FD subtypes, defined by Rome III classification, still have heterogeneous pathogenesis. Previous studies have shown notable differences in visceral sensation processing in the CNS in FD compared to healthy subjects (HS). However, the role of CNS in the pathogenesis of each FD subtype has not been recognized. Methods Twenty-eight FD patients, including 10 epigastric pain syndrome (EPS), 9 postprandial distress syndrome (PDS), and 9 mixed-type, and 10 HS, were enrolled. All subjects underwent a proximal gastric perfusion water load test and the regional brain activities during resting state and water load test were investigated by functional magnetic resonance imaging. Results For regional brain activities during the resting state and water load test, each FD subtype was significantly different from HS (P < 0.05). Focusing on EPS and PDS, the regional brain activities of EPS were stronger than PDS in the left paracentral lobule, right inferior frontal gyrus pars opercularis, postcentral gyrus, precuneus, insula, parahippocampal gyrus, caudate nucleus, and bilateral cingulate cortices at the resting state (P < 0.05), and stronger than PDS in the left inferior temporal and fusiform gyri during the water load test (P < 0.05). Conclusions Compared to HS, FD subtypes had different regional brain activities at rest and during water load test, whereby the differences displayed distinct manifestations for each subtype. Compared to PDS, EPS presented more significant differences from HS at rest, suggesting that the abnormality of central visceral pain processing could be one of the main pathogenesis mechanisms for EPS.

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참고문헌 (25)

참고문헌 신청
Miwa H / 2011 / Current understanding of pathogenesis of functional dyspepsia / J Gastroenterol Hepatol 26(suppl 3):53~60 Crossref Van Oudenhove L / 2004 / Central nervous system involvement in functional gastrointestinal disorders / Best Pract Res Clin GastroenterolBest Pract Res Clin Gastroenterol 18:663~680 Crossref Tack J / 2001 / Symptoms associated with hypersensitivity to gastric distention in functional dyspepsia / Gastroenterology 121:526~535 Crossref Vandenberghe J / 2007 / Regional cerebral blood flow during gastric balloon distention in functional dyspepsia / Gastroenterology 132:1684~1693 Crossref Van Oudenhove L / 2010 / Abnormal regional brain activity duringrest and (anticipated) gastric distension in functional dyspepsia and the role of anxiety: a $H_2$ $^{15}O$-PET study / Am J Gastroenterol 105:913~924 Crossref

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