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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 231 - 239 (9page)
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초록· 키워드
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High sensitivity C-reactive protein (hs-CRP)level is a predictor of cardiovascular disease. We investigatedgene-environment interactions that affect hs-CRPlevels in a community-based cohort. We evaluated theeffects of 11 non-genetic factors on hs-CRP level in 866Korean elderly and performed single marker analyses of 25single-nucleotide polymorphisms (SNPs) in eight loci (i.e.
IL6R, CRP, GCKR, IL6, CYP17A1, HNF1A, APOE, and12q23.2) under each of additive, dominant, and recessivegenetic model. Finally, we evaluated gene-environmentinteractions using generalized linear models with adjustingfor age, sex, and body mass index (BMI). The generallinear model identified several non-genetic risk factorsassociated with hs-CRP level, the most significant examplesof which are high BMI (b = 0.039, P = 5.3 9 10-6),total cholesterol to HDL cholesterol ratio (T/HDL,b = 0.072, P = 2.1 9 10-4), and current smoking status(b = 0.225, P = 0.005). Single SNP analyses for sevengenes revealed strong evidence for associations that affecths-CRP levels (P = 8.9 9 10-5 to 0.032). The interactionsbetween IL6R (rs2228145) and both high T/HDL andsystolic blood pressure (PG9E = 0.009 and 0.045, respectively),CRP (rs7553007) and sleeping less than 8 hoursper day (PG9E = 4.0 9 10-4), IL6 (rs2097677) and currentalcohol drinking (PG9E = 0.026), and HNF1A(rs1169288) with regular exercise (PG9E = 0.035) significantlyincreased the hs-CRP levels in the current study.
Common susceptibility variants and their interactions withnon-genetic factors affect the inter-individual variability ofplasma hs-CRP concentrations.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Albert MA / 2004 / C-reactive protein levels among women of various ethnic groups living in the United States (from the Women’s Health Study) / Am J Cardiol 93:1238~1242
Babaya N / 2003 / Association of I27L polymorphism of hepatocyte nuclear factor-1 alpha gene with high-density lipoprotein cholesterol level / J Clin Endocrinol Metab 88:2548~2551
Barrett JC / 2005 / Haploview: analysis and visualization of LD and haplotype maps / Bioinformatics 21:263~265
Cho YG / 2009 / The relationship between body fat mass and erectile dysfunction in Korean men: Hallym aging study / Int J Impot Res 21:179~186
Choi EY / 2006 / Association of C-reactive protein with the metabolic risk factors among young and middle-aged Koreans / Metabolism 55:415~421
Babaya N / 2003 / Association of I27L polymorphism of hepatocyte nuclear factor-1 alpha gene with high-density lipoprotein cholesterol level / J Clin Endocrinol Metab 88:2548~2551
Barrett JC / 2005 / Haploview: analysis and visualization of LD and haplotype maps / Bioinformatics 21:263~265
Cho YG / 2009 / The relationship between body fat mass and erectile dysfunction in Korean men: Hallym aging study / Int J Impot Res 21:179~186
Choi EY / 2006 / Association of C-reactive protein with the metabolic risk factors among young and middle-aged Koreans / Metabolism 55:415~421
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