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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 148 - 154 (7page)
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Crinum asiaticum var. japonicum and its active component, norgalanthamine have been reported to have hair growth-promoting effect via the proliferation of dermal papilla cells. In this study, we investigated the other mechanisms of C. asiaticum extract var. japonicum and norgalanthamine on the hair growth. The C. asiaticum var. japonicum extract inhibited 5α-reductase activity by 16%, which converts testosterone to dihydrotestosterone (DHT), a main cause of androgenetic alopecia, whereas the C. asiaticum var. japonicum extract didn`t function as an opener of the K<sub>ATP</sub> channel. On the other hand, we examined whether norgalanthamine can inhibit transforming growth factor-β (TGF-β) signal pathway, which is essential in the regression induction of hair growth. Norgalanthamine inhibited the phosphorylation of Smad2/3 on TGF-β1-induced canonical pathway in human keratinocyte HaCaT cells. These results suggested that the C. asiaticum var. japonicum extract and norgalanthamine had the potential to influence hair growth through the inhibition of 5α-reductase activity and TGF-β1-induced canonical pathway.
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참고문헌 (38)
참고문헌 신청
Price, V. H. / 1999 / Treatment of hair loss / N. Engl. J. Med. 341:964~973
Ellis, J. A. / 2002 / Androgenetic alopecia: pathogenesis and potential for therapy / Expert. Rev. Mol. Med. 4:1~11
Elliott, K. / 1999 / Differences in hair follicle dermal papilla volume are due to extracellular matrix volume and cell number: implications for the control of hair follicle size and androgen responses / J. Invest. Dermatol 113:873~877
Kaufman, K. D. / 2002 / Androgens and alopecia / Mol. Cell Endocrinol 198:89~95
Botchkarev, V. A. / 2003 / Molecular mechanisms of chemotherapy-induced hair loss / J. Investig. Dermatol. Symp. Proc 8:72~75
Ellis, J. A. / 2002 / Androgenetic alopecia: pathogenesis and potential for therapy / Expert. Rev. Mol. Med. 4:1~11
Elliott, K. / 1999 / Differences in hair follicle dermal papilla volume are due to extracellular matrix volume and cell number: implications for the control of hair follicle size and androgen responses / J. Invest. Dermatol 113:873~877
Kaufman, K. D. / 2002 / Androgens and alopecia / Mol. Cell Endocrinol 198:89~95
Botchkarev, V. A. / 2003 / Molecular mechanisms of chemotherapy-induced hair loss / J. Investig. Dermatol. Symp. Proc 8:72~75
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