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논문 기본 정보

자료유형
학술저널
저자정보
Evelyn Saba (Pir Mehr Ali Shah Arid Agriculture University) Nayeong Je (Kyungpook National University) Ji Eun Song (Kyungpook National University) Sangwoo Shi (Kyungpook National University) Juho Lee (Kyungpook National University) Oneyoung Jung (Kyungpook National University) Beom Jun Han (Kyungpook National University) Soo Young Lee (Kyungpook National University) Jongwon Park (Kyungpook National University) Yuan Yee Lee (University of Maryland) Man Hee Rhee (Kyungpook National University)
저널정보
대한의생명과학회 대한의생명과학회지 대한의생명과학회지 제28권 제3호
발행연도
2022.9
수록면
170 - 177 (8page)

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초록· 키워드

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In mountainous regions, wild herbs which can also be edible in nature for humans and animals possess a wide array of biologically diversified properties. It is because of the fact that due to the cold weather of mountains; they are enriched in certain kinds of phytochemicals such as anti-oxidants, anti-inflammatory and many more. One such kind of an herb is Aster scaber (AS) in Korean. It is a widely cultivated culinary herb in Korean peninsula and used as a side dish in Korean culinary cuisine. In view of its extensive use in cuisine, we geared to unravel the anti-oxidant and anti-inflammatory effects of AS in murine alveolar macrophage cell line (MH-S). 2,2"-Azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) assays revealed a dose dependent (7.8~1,000 μg/mL) inhibition of oxidation by AS 70% ethanol (ASE) extract as compared to Trolox and Ascorbic acid respectively. Nitric oxide assay (NO) showed a dose dependent decrease (5~40 μg/mL) in MH-S cells with ASE when stimulated with Coal Fly Ash (CFA). Moreover, this dose for NO reduction was also found to be least cytotoxic for cells as determined by cellular viability (MTT) assay. The gene expression of pro-inflammatory mediators (iNOS and COX-2) and cytokines (IL-6 and IL-1β) and were also dose dependently inhibited by ASE in MH-S cells through RT-PCR. Therefore, in light of these findings, AS exhibited a strong anti-oxidant and anti-inflammatory agent. These results also justify the extensive use of this mountainous herb in culinary practices for beneficial effects on human health.

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INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

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