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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.3
- 수록면
- 28 - 35 (8page)
- DOI
- 10.20307/nps.2021.27.1.28
이용수
초록· 키워드
오류제보하기
The aim of this study was to anatomize the therapeutic potential of alaternin (=7-hydroxyemodin) against inflammation, advanced glycation end products (AGEs) formation, tyrosinase, and two cyclin-dependent kinases (CDKs), CDK2 and CDK4, and compare its potency with emodin. Alaternin showed lower cytotoxicity and higher dose-dependent inhibition against lipopolysaccharide (LPS) induced nitric oxide (NO) production with half maximal inhibitory concentration (IC<SUB>50</SUB>) of 18.68 μM. Similarly, alaternin efficaciously inhibited biotransformation of fluorescent AGEs and amyloid cross-β structure on the bovine serum albumin (BSA)-glucose-fructose system, five times more than emodin. Interestingly, alaternin also showed selective activity against CDK4 at 170 μM, whereas emodin inhibited both CDK2 and CDK4 at a concentration of 17 and 380 μM respectively. In addition, alaternin showed dose-dependent inhibitory activity against mushroom tyrosinase with inhibition percentage of 35.84 % at 400 μM. Altogether, alaternin with pronounced inhibition against inflammatory mediator (NO), glycated products formation, and targeted inhibition towards CDK4 receptor can be taken as an important candidate to target multiple diseases.
목차
Abstract
Introduction
Experimental
Result and Discussion
References
참고문헌 (80)
참고문헌 신청
Ali, M. Y. / 2018 / J. Food Biochem. 42:e12439
Pradeep Paudel / 2018 / Anthraquinone and naphthopyrone glycosides from Cassia obtusifolia seeds mediate hepatoprotection via Nrf2-mediated HO-1 activation and MAPK modulation / Archives of Pharmacal Research 41(6):677~689
Jung, H. A. / 2016 / J. Ethnopharmacol. 191:152~160
Khan, K. / 2011 / Int. J. Appl. Res. Nat. Prod. 4:28~36
Kwon, K. S. / 2018 / Phytother. Res 32:1537~1545
Pradeep Paudel / 2018 / Anthraquinone and naphthopyrone glycosides from Cassia obtusifolia seeds mediate hepatoprotection via Nrf2-mediated HO-1 activation and MAPK modulation / Archives of Pharmacal Research 41(6):677~689
Jung, H. A. / 2016 / J. Ethnopharmacol. 191:152~160
Khan, K. / 2011 / Int. J. Appl. Res. Nat. Prod. 4:28~36
Kwon, K. S. / 2018 / Phytother. Res 32:1537~1545
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