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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 149 - 156 (8page)
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초록· 키워드
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Excessive glutamate can cause oxidative stress in neuronal cells and this can be the reason for neurodegenerative disease. In this study, we investigated the protective effect of Spirulina maxima hot ethanol extract on mouse hippocampal HT22 cell of which glutamate receptor has no function. HT22 cells were pre-treated with S. maxima sample at a dose dependent manner (1, 10 and 100 ㎍/ml). After an hour, glutamate was treated. Cell viability, reactive oxygen species (ROS) accumulation, Ca<SUP>2+</SUP> influx, decrease of mitochondrial membrane potential level and glutathione related assays were followed by then. S. maxima ethanol extract improved the cell viability by suppressing the ROS and Ca<SUP>2+</SUP> formation, retaining the mitochondrial membrane potential level and protecting the activity of the antioxidant enzymes compared with group of vehicle-treated controls. These suggest that S. maxima may decelerate the neurodegeneration by attenuating neuronal damage and oxidative stress.
목차
Abstract
재료 및 방법
결과 및 고찰
결론
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참고문헌 (26)
참고문헌 신청
Morais, L. C. S. L. / 2003 / Plants and bioactive compounds for the treatment of Parkinson’s disease / Arqui. Brasil. Fitomed. Cientí 1:127~131
Ahmad, M. / 2005 / Ginkgo biloba affords dose-dependent protection against 6-hydroxydopamine-induced parkinsonism in rats : Neurobehavioural, neurochemical and immunohistochemical evidence / J. Neurochem 93:94~104
Gil-Saeng Jeong / 2010 / Neuroprotective Effects of Constituents of the Root Bark of Dictamnus dasycarpus in Mouse Hippocampal Cells / Archives of Pharmacal Research 33(8):1269~1275
Jeong, G. S. / 2010 / Cytoprotective and anti-inflammatory effects of spinasterol via the induction of heme oxygenase-1 in murine hippocampal and microglial cell lines / Int. Immunopharmacol 10:1587~1594
Melo, A. / 2011 / Oxidative stress in neurodegenerative diseases : Mechanisms and therapeutic perspectives / Oxid. Med. Cell. Longev 2011:467180
Ahmad, M. / 2005 / Ginkgo biloba affords dose-dependent protection against 6-hydroxydopamine-induced parkinsonism in rats : Neurobehavioural, neurochemical and immunohistochemical evidence / J. Neurochem 93:94~104
Gil-Saeng Jeong / 2010 / Neuroprotective Effects of Constituents of the Root Bark of Dictamnus dasycarpus in Mouse Hippocampal Cells / Archives of Pharmacal Research 33(8):1269~1275
Jeong, G. S. / 2010 / Cytoprotective and anti-inflammatory effects of spinasterol via the induction of heme oxygenase-1 in murine hippocampal and microglial cell lines / Int. Immunopharmacol 10:1587~1594
Melo, A. / 2011 / Oxidative stress in neurodegenerative diseases : Mechanisms and therapeutic perspectives / Oxid. Med. Cell. Longev 2011:467180
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