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논문 기본 정보

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학술저널
저자정보
Park Younhee (Department of Laboratory Medicine Severance Hospital Yonsei University College of Medicine Seoul Ko) Hong Ki Ho (Department of Laboratory Medicine Severance Hospital Yonsei University College of Medicine Seoul Ko) Lee Su-Kyung (Department of Laboratory Medicine Hallym University Dongtan Sacred Heart Hospital Hallym University) Hyun Jungwon (Department of Laboratory Medicine Hallym University Dongtan Sacred Heart Hospital Hallym University) Oh Eun-Jee (Department of Laboratory Medicine Seoul St. Mary's Hospital College of Medicine The Catholic Univer) Lee Jaehyeon (Department of Laboratory Medicine Jeonbuk National University Medical School and Hospital Jeonju Ko) Lee Hyukmin (Department of Laboratory Medicine Severance Hospital Yonsei University College of Medicine Seoul Ko) Song Sang Hoon (Department of Laboratory Medicine Seoul National University Hospital and College of Medicine Seoul) Kee Seung-Jung (Department of Laboratory Medicine Chonnam National University Medical School and Hospital Gwangju K) Kwon Gye Cheol (Department of Laboratory Medicine College of Medicine Chungnam National University Daejeon Korea) Kim Su Hwan (Center for Vaccine Research National Institute of Infectious Diseases National Institute of Health) Do Hyeon-Nam (Center for Vaccine Research National Institute of Infectious Diseases National Institute of Health) Kim Ah-Ra (Center for Vaccine Research National Institute of Infectious Diseases National Institute of Health) Lee June-Woo (Center for Vaccine Research National Institute of Infectious Diseases National Institute of Health) Kim Sung Soon (Center for Vaccine Research National Institute of Infectious Diseases National Institute of Health) Kim Hyun Soo (Department of Laboratory Medicine Hallym University Dongtan Sacred Heart Hospital Hallym University)
저널정보
대한진단검사의학회 Annals of Laboratory Medicine Annals of Laboratory Medicine 제42권 제1호
발행연도
2022.1
수록면
71 - 78 (8page)
DOI
10.3343/alm.2022.42.1.71

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Background: Seroprevalence studies of coronavirus disease 2019 (COVID-19) cases, including asymptomatic and past infections, are important to estimate the scale of the disease outbreak and to establish quarantine measures. We evaluated the clinical performance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody assays available in Korea for use in seroprevalence studies. Methods: The sensitivity, specificity, cross-reactivity, and interference of five SARS-CoV-2 antibody assays were evaluated using the following: 398 serum samples from confirmed COVID-19 patients, 510 negative control samples from before 2018 (pre-pandemic), 163 serum samples from patients with SARS, Middle East respiratory syndrome (MERS), and other viral infections, and five samples for the interference study. Results: The sensitivities of the five assays ranged from 92.2% to 98%, and their specificities, including cross-reactivity and interference, ranged from 97.5% to 100%. The agreement rates were excellent (kappa >0.9). Adjustment of the cutoff values could be considered through ROC curve analysis. The positive predictive values of the individual assays varied from 3.5% to 100% at a 0.1% prevalence but were as high as ≥95% when two assays were combined. Conclusions: The prevalence of COVID-19 in Korea is considered to be exceptionally low at present; thus, we recommend using a combination of two or more SARS-CoV-2 antibody assays rather than a single assay. These results could help select SARS-CoV-2 antibody assays for COVID-19 seroprevalence studies in Korea.
#COVID-19 #SARS-CoV-2 #Antibody #Seroprevalence

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