Expression of prostate-specific membrane antigen in the neovasculature of primary tumors and lymph node metastasis of laryngeal squamous cell carcinomas

Gamze Erkılınç; Hasan Yasan; Yusuf Çağdaş Kumbul; Mehmet Emre Sivrice; Meltem Durgun

doi:10.4132/jptm.2022.02.22

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자료유형: 학술저널

저자정보: Gamze Erkılınç (Süleyman Demirel Univesity) Hasan Yasan (Süleyman Demirel Univesity) Yusuf Çağdaş Kumbul (Süleyman Demirel Univesity) Mehmet Emre Sivrice (Süleyman Demirel Univesity) Meltem Durgun (Süleyman Demirel Univesity)

저널정보: 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제56권 제3호

발행연도: 2022.5

수록면: 134 - 143 (10page)

DOI: 10.4132/jptm.2022.02.22

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Background: Prostate-specific membrane antigen (PSMA) expression is encountered in tumor-associated neovascularization. Methods: PSMA-antibody was applied to the paraffin blocks of 51 patients who were diagnosed with squamous cell carcinoma of the larynx and underwent laryngectomy and one who underwent lymph node dissection. The percentage of vascular expression in tumoral and extratumoral stroma and lymph nodes and intensity score in tumoral epithelium were evaluated and divided into groups according to the level of PSMA expression. Final PSMA expression was determined by multiplying intensity and percentage scores. Results: The mean age was 61 ± 10 years. Patients with perineural invasion, cartilage invasion, and local invasion exhibited higher PSMA expression scores. Age, tumor differentiation, tumor diameter, perineural invasion, tumor localization, capsular invasion, depth of invasion, surgical margin status, local invasion, nodal metastasis, TNM classification, and stage were similar in high and low PSMA expression groups. There was no PSMA expression in extratumoral vascular stroma. Significantly higher PSMA expression was observed in the vascular endothelium of metastatic lymph nodes compared with reactive lymph nodes. Patients with advanced-stage disease exhibited higher PSMA vascular expression scores compared to those with earlier stages (p < .001). PSMA expression was not correlated with overall survival, disease-specific survival, or disease-free survival (p > .05). Conclusions: Our study suggests that higher PSMA expression is associated with cartilage invasion, local invasion, and advanced-stage of disease. PSMA expression can be utilized for detection of lymph node metastasis and has some predictive role in cases of neck metastasis.

#Prostate-specific membrane antigen #Larynx #Lymph nodes #Neovascularization #Immunohistochemistry

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