Pharmacological interactions between intrathecal pregabalin plus tianeptine or clopidogrel in a rat model of neuropathic pain

Hyung Gon Lee; Yeo Ok Kim; Jeong Il Choi; Xue Hao Han; Yang Un Shin; Myung Ha Yoon

doi:10.3344/kjp.2022.35.1.59

추천

검색

자료유형: 학술저널

저자정보: Hyung Gon Lee (Chonnam National University Medical School) Yeo Ok Kim (Chonnam National University Medical School) Jeong Il Choi (Chonnam National University Medical School) Xue Hao Han (Chonnam National University Medical School) Yang Un Shin (Chonnam National University Medical School) Myung Ha Yoon (Chonnam National University Medical School)

저널정보: 대한통증학회 The Korean Journal of Pain The Korean Journal of Pain 제35권 제1호

발행연도: 2022.1

수록면: 59 - 65 (7page)

DOI: 10.3344/kjp.2022.35.1.59

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: There is still unmet need in treating neuropathic pain and increasing awareness regarding the use of drug combinations to increase the effectiveness of treatment and reduce adverse effects in patients with neuropathic pain. Methods: This study was performed to determine the individual and combined effects of pregabalin, tianeptine, and clopidogrel in a rat model of neuropathic pain. The model was created by ligation of the L5-L6 spinal nerve in male Sprague?Dawley rats; mechanical allodynia was confirmed using von Frey filaments. Drugs were administered to the intrathecal space and mechanical allodynia was assessed; drug interactions were estimated by isobolographic or fixed-dose analyses. Results: Intrathecal pregabalin and tianeptine increased the mechanical withdrawal threshold in a dose-dependent manner, but intrathecal clopidogrel had little effect on the mechanical withdrawal threshold. An additive effect was noted between pregabalin and tianeptine, but not between pregabalin and clopidogrel. Conclusions: These findings suggest that intrathecal coadministration of pregabalin and tianeptine effectively attenuated mechanical allodynia in the rat model of neuropathic pain. Thus, pregabalin plus tianeptine may be a valid option to enhance the efficacy of neuropathic pain treatment.

#Chronic Pain #Clopidogrel #Drug Interactions #Hyperalgesia #Neuralgia #Pregabalin #Rats #Spinal Nerves #Tianeptine.

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!