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자료유형
학술저널
저자정보
김홍식 (삼성서울병원) 박세훈 (삼성서울병원) 정현애 (삼성서울병원) 선종무 (삼성서울병원) 이세훈 (삼성서울병원) 안진석 (삼성서울병원) 박근칠 (성균관대학교(자연과학캠퍼스) 삼성융합의과학원) 안명주 (삼성서울병원)
저널정보
대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제54권 제1호
발행연도
2022.1
수록면
150 - 156 (7page)
DOI
10.4143/crt.2021.306

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Purpose Metachronous brain-only oligorecurrence in patients with non?small cell lung cancer (NSCLC) is a rare event with favorable prognosis, but the clinical outcome has not been fully determined. We retrospectively analyzed clinical outcomes and prognostic factors in metachronous brain-only oligorecurrence in patients with NSCLC who underwent definitive treatment. Materials and Methods We reviewed 4,437 NSCLC patients without oncogenic driver mutations who underwent definitive treatment between 2008 and 2018. Among them, we identified 327 patients who developed 1 to 5 brain metastases with or without systemic metastasis. Of the 327 patients, 71 had metachronous brain-only oligorecurrence without extracranial progression and were treated with local therapy to the brain. Overall survival (OS), progression-free survival (PFS), and prognostic factors affecting OS were analyzed. Results The median OS was 38.9 months (95% confidence interval [CI], 21.8 to 56.1 months) in 71 patients. The 2-year OS rate was 67.8% and the 5-year OS rate was 33.1%. The median PFS was 25.5 months (95% CI, 12.2 to 14.4 months). The longest surviving patient had a survival period of 115 months. Through multivariate analysis, Eastern Cooperative Oncology Group ≥ 1 (hazard ratio, 5.33; p=0.005) was associated with poor survival. There was no significant difference in OS between patients with local therapy and those with local plus systemic therapy (18.5 months vs. 34.7 months, p=0.815). Conclusion Metachronous brain-only oligorecurrence NSCLC patients who underwent definitive treatment experienced long-term survival with local therapy, highlighting the unique patient population. The role of systemic chemotherapy in this patient population requires further investigation.

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