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논문 기본 정보

자료유형
학술저널
저자정보
Mujahid Edy Husnul (Department of Psychiatry Faculty of Medicine Hasanuddin University Makassar Indonesia) Limoa Erlyn (Department of Psychiatry Faculty of Medicine Hasanuddin University Makassar Indonesia) Syamsuddin Saidah (Department of Psychiatry Faculty of Medicine Hasanuddin University Makassar Indonesia) Bahar Burhanuddin (Faculty of Public Health Hasanuddin University Makassar Indonesia) Renaldi Rinvil (Department of Psychiatry Faculty of Medicine Hasanuddin University Makassar Indonesia) Aminuddin Aminuddin (Department of Clinical Nutrition Faculty of Medicine Hasanuddin University Makassar Indonesia) Lisal Sonny T. (Department of Psychiatry Faculty of Medicine Hasanuddin University Makassar Indonesia)
저널정보
대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제19권 제11호
발행연도
2022.11
수록면
898 - 908 (11page)
DOI
10.30773/pi.2022.0064

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Objective This study aims to examine the effect of giving probiotic adjuvant therapy on improving clinical symptoms & IL-6 levels in patients with schizophrenia.Methods This research was a double-blind, placebo-controlled trial conducted at Dadi Psychiatric Hospital, South Sulawesi Province, Indonesia in November–December 2021. The sample of the research was patients with schizophrenia undergoing hospitalization who received therapeutic doses of risperidone with a total of 21 samples in each treatment and control group. Research subjects were measured with Positive and Negative Syndrome Scale (PANSS) at baseline, 2nd, 4th, and 6th weeks. The treatment group received one capsule/12 hours/oral of probiotics for six weeks and the control group received 1 capsule/12 hours/oral placebo for 6 weeks. In addition, two measurements of IL-6 using enzyme-linked immunosorbent assay were performed in both groups, namely at the beginning of week 0 and the end of the 6th week.Results We found the decrease in the PANSS value which described the improvement in clinical symptoms of the schizophrenic group after receiving therapeutic doses of antipsychotics and probiotic capsules or the treatment group as well as the schizophrenia group receiving therapeutic doses of antipsychotics and placebo capsules or the control group.Conclusion Improvements in clinical symptoms and decreased levels of IL-6 in the group of patients with schizophrenia who received risperidone with probiotic adjuvant therapy were better than in the group of patients with schizophrenia who received risperidone without probiotics as adjuvant therapy.

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