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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 450 - 456 (7page)
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Mammalian physiology and behavior are regulated by an internal time-keeping system, referred to as circadian rhythm. The circadian timing system has a hierarchical organization composed of the master clock in the suprachiasmatic nucleus (SCN) and local clocks in extra-SCN brain regions and peripheral organs. The circadian clock molecular mechanism involves a network of transcription-translation feedback loops. In addition to the clinical association between circadian rhythm disruption and mood disorders, recent studies have suggested a molecular link between mood regulation and circadian rhythm. Specifically, genetic deletion of the circadian nuclear receptor Rev-erbα induces mania-like behavior caused by increased midbrain dopaminergic (DAergic) tone at dusk. The association between circadian rhythm and emotion-related behaviors can be applied to pathological conditions, including neurodegenerative diseases. In Parkinson’s disease (PD), DAergic neurons in the substantia nigra pars compacta progressively degenerate leading to motor dysfunction. Patients with PD also exhibit non-motor symptoms, including sleep disorder and neuropsychiatric disorders. Thus, it is important to understand the mechanisms that link the molecular circadian clock and brain machinery in the regulation of emotional behaviors and related midbrain DAergic neuronal circuits in healthy and pathological states. This review summarizes the current literature regarding the association between circadian rhythm and mood regulation from a chronobiological perspective, and may provide insight into therapeutic approaches to target psychiatric symptoms in neurodegenerative diseases involving circadian rhythm dysfunction.
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참고문헌 (85)
참고문헌 신청
Aarsland, D. / 2011 / Depression in Parkinson disease--epidemiology, mechanisms and management / Nat. Rev. Neurol 8:35~47
Abarca, C. / 2002 / Cocaine sensitization and reward are under the influence of circadian genes and rhythm / Proc. Natl. Acad. Sci. USA 99:9026~9030
Akhtar, R. A. / 2002 / Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus / Curr. Biol 12:540~550
Albrecht, U. / 2013 / Circadian clocks and mood-related behaviors / Handb. Exp. Pharmacol 217:227~239
Albrecht, U. / 2017 / Molecular mechanisms in mood regulation involving the circadian clock / Front Neurol 8:30
Abarca, C. / 2002 / Cocaine sensitization and reward are under the influence of circadian genes and rhythm / Proc. Natl. Acad. Sci. USA 99:9026~9030
Akhtar, R. A. / 2002 / Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus / Curr. Biol 12:540~550
Albrecht, U. / 2013 / Circadian clocks and mood-related behaviors / Handb. Exp. Pharmacol 217:227~239
Albrecht, U. / 2017 / Molecular mechanisms in mood regulation involving the circadian clock / Front Neurol 8:30
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