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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 367 - 376 (10page)
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초록· 키워드
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Cryptochrome 1 (CRY1) is well known as a circadian clock repressor. Recent studies have shown that it could intimately associate with nuclear receptors and either activate or inhibit its targets at the transcriptional level. In the present study, we applied publicly available transcriptional factors Chromatin Immunoprecipitation coupled high throughput sequencing data to prove that CRY1 associates with various nuclear receptors at the genomewide level, which is independent of its canonical role as a circadian clock repressor. Furthermore, we have also shown that CRY1 is a confident co-receptor of retinoid X receptor, alpha (RXRa). We have also further shown that CRY1 could directly interact with RXRa. The interaction was regulated by retinoic acid treatment in a dose-dependent manner. In addition, CRY activator could antagonized RA-medicated PCK1 and G6PC expression, which in turn antagonize glucose production. Our findings indicate that CRYs could be potential targets in relieving side effects of RA-oriented treatment for diseases such as leukemia, acne, and psoriasis.
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등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Bailey TL / 2009 / MEME SUITE: tools for motif discovery and searching / Nucl Acids Res 37:W202~W208
Barnes PJ / 1998 / Anti-inflammatory actions of glucocorticoids: molecular mechanisms / Clin Sci 94:557~572
Bershad S / 1985 / Changes in plasma lipids and lipoproteins during isotretinoin therapy for acne / New Engl J Med 313:981~985
Chakravarty K / 2005 / Factors that control the tissue-specific transcription of the gene for phosphoenolpyruvate carboxykinase-C / Crit Rev Biochem Mol Biol 40:129~154
Evans RM / 1988 / The steroid and thyroid hormone receptor superfamily / Science 240:889~895
Barnes PJ / 1998 / Anti-inflammatory actions of glucocorticoids: molecular mechanisms / Clin Sci 94:557~572
Bershad S / 1985 / Changes in plasma lipids and lipoproteins during isotretinoin therapy for acne / New Engl J Med 313:981~985
Chakravarty K / 2005 / Factors that control the tissue-specific transcription of the gene for phosphoenolpyruvate carboxykinase-C / Crit Rev Biochem Mol Biol 40:129~154
Evans RM / 1988 / The steroid and thyroid hormone receptor superfamily / Science 240:889~895
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