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논문 기본 정보

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학술저널
저자정보
Joo Eunwook (Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul Nationa) Park Kyo Hoon (Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul Nationa) Kim Yu Mi (Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul Nationa) Ahn Kwanghee (Department of Obstetrics and Gynecology Seoul National University College of Medicine Seoul Nationa) Hong Subeen (Department of Obstetrics and Gynecology College of Medicine The Catholic University of Korea Seoul)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.44
발행연도
2021.11
수록면
1 - 13 (13page)
DOI
10.3346/jkms.2021.36.e279

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Background: We sought to determine whether lipopolysaccharide binding protein (LBP), pentraxin 3, resistin, and insulin-like growth factor binding protein (IGFBP)-3 in plasma and amniotic fluid (AF) can predict microbial invasion of the amniotic cavity (MIAC), intra-amniotic inflammation (IAI), and microbial-associated IAI in women with preterm premature rupture of membranes (PPROM). Methods: This was a retrospective cohort study involving 168 singleton pregnant women with PPROM. AF obtained via amniocentesis was cultured and assayed for interleukin (IL)-6 to define IAI and for IL-8 to compare with AF biomarkers. Plasma samples were collected at the time of amniocentesis, and C-reactive protein (CRP) levels in serum were compared with plasma biomarkers. The stored plasma and AF samples were assayed for LBP, pentraxin 3 (PTX3), resistin, and IGFBP-3 by ELISA. Results: Multivariate logistic regression analysis revealed that: 1) elevated plasma and AF levels of LBP were independently associated with increased risks of MIAC, IAI, and microbial-associated IAI; 2) elevated AF, but not plasma, PTX3, and resistin levels were independently associated with increased risks of MIAC, IAI, and microbial-associated IAI; 3) decreased IGFBP-3 levels in the plasma were independently associated with only IAI, whereas those in the AF were associated with only microbial-associated IAI. Among the tested biomarkers, AF PTX3 and resistin had the highest predictive performance for MIAC, IAI, and microbial-associated IAI (area under the curves [AUC] = 0.85?0.95), which is similar to the performance of AF IL-8. The AUCs of the plasma LBP and IGFBP-3 were similar to that of serum CRP with respect to IAI. Conclusion: Maternal plasma LBP and IGFBP-3 are potential biomarkers for the non-invasive identification of IAI in women with PPROM, with a similar accuracy to the serum CRP level. AF LBP, PTX3, resistin, and IGFBP-3 may be involved in the intra-amniotic inflammatory responses in PPROM complicated by MIAC.
#Amniotic Fluid #Intra-Amniotic Inflammation #IGFBP-3 #Inflammatory Mediators #Microbial Invasion of Amniotic Cavity #Plasma #Preterm Premature Rupture of Membranes

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참고문헌 (47)

참고문헌 신청
Mercer BM / 2003 / Preterm premature rupture of the membranes / Obstet Gynecol 101(1):178~193 google schola Manuck TA / 2014 / Neonatal and early childhood outcomes following early vs later preterm premature rupture of membranes / Am J Obstet Gynecol 211(3):308.e1~308.e6 google schola Menon R / 2017 / Preterm prelabor rupture of the membranes : a disease of the fetal membranes / Semin Perinatol 41(7):409~419 google schola Sae-Lin P / 2019 / Incidence and risk factors of preterm premature rupture of membranes in singleton pregnancies at Siriraj Hospital / J Obstet Gynaecol Res 45(3):573~577 google schola Goldenberg RL / 2008 / Epidemiology and causes of preterm birth / Lancet 371(9606):75~84 google schola

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