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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제5권 제4호
- 발행연도
- 2017.7
- 수록면
- 232 - 236 (5page)
- DOI
- https://doi.org/10.4168/aard.2017.5.4.232
이용수
초록· 키워드
오류제보하기
Hypereosinophilic syndrome (HES) is a heterogeneous disorder characterized by persistent hypereosinophilia with the evidence of organ dysfunction caused by eosinophilic involvement. HES can be induced by various secondary causes, including helminthic infections, adverse drug reactions, and allergic diseases. Primary/clonal bone marrow disease, including genetic mutations in platelet driven growth factor receptor alpha (PDGFRA), platelet driven growth factor receptor beta (PDGFRB), and fibroblast growth factor receptor 1 (FGFR1) could be its causes. Although corticosteroids are the mainstay of therapy in confirmed HES, imatinib is considered a definitive treatment for HES with these mutations. However, there have been few reports about HES with these genetic mutations in Korea. Here, we report a patient who presented with sudden onset of congestive heart failure and hypereosinophilia, proved to have PDGFRB rearrangement, and was controlled successfully with imatinib after left ventricle thrombectomy.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Haferlach T / 2008 / The diagnosis of BCR/ABL-negative chronic myeloproliferative diseases (CMPD): a comprehensive approach based on morphology, cytogenetics, and molecular markers / Ann Hematol 87:1~10
김태희 / 2016 / Chronic eosinophilic leukemia with FIP1L1-PDGFRA rearrangement / Blood Research 51(3):204~206
Kim M / 2005 / A case of chronic myelomonocytic leukemia with severe eosinophilia having t(5;12)(q31;p13) with t(1;7)(q10;p10) / Acta Haematol 114:104~107
장상언 / 2010 / 호산구증가증과 PDGFRB 유전자 재배열을 보인 골수종양 1예 / 대한내과학회지 78(3):386~390
Hee-Jin Kim / 2015 / Chronic eosinophilic leukemia with a FIP1L1-PDGFRA rearrangement: Two case reports and a review of Korean cases / Blood Research 50(1):58~61
김태희 / 2016 / Chronic eosinophilic leukemia with FIP1L1-PDGFRA rearrangement / Blood Research 51(3):204~206
Kim M / 2005 / A case of chronic myelomonocytic leukemia with severe eosinophilia having t(5;12)(q31;p13) with t(1;7)(q10;p10) / Acta Haematol 114:104~107
장상언 / 2010 / 호산구증가증과 PDGFRB 유전자 재배열을 보인 골수종양 1예 / 대한내과학회지 78(3):386~390
Hee-Jin Kim / 2015 / Chronic eosinophilic leukemia with a FIP1L1-PDGFRA rearrangement: Two case reports and a review of Korean cases / Blood Research 50(1):58~61
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