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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제4호
- 발행연도
- 2017.7
- 수록면
- 415 - 421 (7page)
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초록· 키워드
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We investigated the inhibitory effect of escitalopram, a selective serotonin reuptake inhibitor (SSRI), on voltage-dependent K+ (Kv) channels in freshly separated from rabbit coronary arterial smooth muscle cells. The application of escitalopram rapidly inhibited vascular Kv channels. Kv currents were progressively inhibited by an increase in the concentrations of escitalopram, suggesting that escitalopram inhibited vascular Kv currents in a concentration-dependent manner.
The IC50 value and Hill coefficient for escitalopram-induced inhibition of Kv channels were 9.54±1.33 μM and 0.75±0.10, respectively. Addition of escitalopram did not alter the steady-state activation and inactivation curves, suggesting that the voltage sensors of the channels were not affected. Pretreatment with inhibitors of Kv1.5 and/ or Kv2.1 did not affect the inhibitory action of escitalopram on vascular Kv channels.
From these results, we concluded that escitalopram decreased the vascular Kv current in a concentration-dependent manner, independent of serotonin reuptake inhibition.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Garnock-Jones KP / 2010 / Escitalopram : a review of its use in the management of major depressive disorder in adults / CNS Drugs 24:769~796
Waugh J / 2003 / Escitalopram : a review of its use in the management of major depressive and anxiety disorders / CNS Drugs 17:343~362
Bolton JM / 2006 / Genital anaesthesia persisting six years after sertraline discontinuation / J Sex Marital Ther 32:327~330
Chae YJ / 2014 / Escitalopram block of hERG potassium channels / Naunyn Schmiedebergs Arch Pharmacol 387:23~32
Haddy FJ / 2006 / Role of potassium in regulating blood flow and blood pressure / Am J Physiol Regul Integr Comp Physiol 290:R546~R552
Waugh J / 2003 / Escitalopram : a review of its use in the management of major depressive and anxiety disorders / CNS Drugs 17:343~362
Bolton JM / 2006 / Genital anaesthesia persisting six years after sertraline discontinuation / J Sex Marital Ther 32:327~330
Chae YJ / 2014 / Escitalopram block of hERG potassium channels / Naunyn Schmiedebergs Arch Pharmacol 387:23~32
Haddy FJ / 2006 / Role of potassium in regulating blood flow and blood pressure / Am J Physiol Regul Integr Comp Physiol 290:R546~R552
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