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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 441 - 448 (8page)
- DOI
- https://doi.org/10.9799/ksfan.2021.34.5.441
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초록· 키워드
오류제보하기
This study was designed to investigate the intracellular signaling pathways and immunoenhancing effect of macrophage activation by crude polysaccharides (CPP) extracted from citrus peels. CPP did not affect the cytotoxicity of RAW264.7 cells, but showed dose-dependent effects on cell viability. Also, CPP showed high production of chemokine (nitric oxide (NO)) and cytokines (interleukin (IL)-6 and tumor necrosis factor (TNF)-α). CPP increased IL-6, TNF-α, and inducible nitric oxide synthase (iNOS) mRNA expression dose-dependently. CPP also strongly induced the phosphorylation of the ERK, p38, and IκBα pathways in RAW 264.7 cells. In anti-pattern recognition receptors (PRRs) experiments, the effect of CPP on NO production was strongly suppressed by neutralizing toll-like receptor (TLR)2, TLR4, and Dectin1 antibodies, whereas IL-6 and TNF-α production by CPP was mainly suppressed by mannose receptor (MR). Therefore, these results suggest that CPP treatment-induced NO production was regulated by the ERK, p38, and NF-κB pathways through TLR2, TLR4, and Dectin1 receptors, whereas IL-6 and TNF-α production was primarily regulated by the ERK, p38, and NF-κB pathways through MR receptors.
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참고문헌 (30)
참고문헌 신청
Deng C / 2018 / Dectin-1mediates the immunoenhancement effect of the polysaccharide from Dictyophora indusiata / Int J Biol Macromol 109:369~374
Doco T / 2003 / Polysaccharides from grape berry cell walls. Part II. Structural characterization of the xyloglucan polysaccharides / Carbohydr Polym 53:253~261
Forman HJ / 2002 / Reactive oxygen species and cell signaling : Respiratory burst in macrophage signaling / Am J Respir Crit Care Med 166:S4~S8
Honda S / 1989 / High-performance liquid chromatography of reducing carbohydrates as strongly ultraviolet-absorbing and electrochemically sensitive 1-phenyl-3-methyl-5-pyrazolone derivatives / Anal Biochem 180:351~357
Huang H / 2009 / Distinct patterns of dendritic cell cytokine release stimulated by fungal β-glucans and Toll-like receptor agonists / Infect Immun 77:1774~1781
Doco T / 2003 / Polysaccharides from grape berry cell walls. Part II. Structural characterization of the xyloglucan polysaccharides / Carbohydr Polym 53:253~261
Forman HJ / 2002 / Reactive oxygen species and cell signaling : Respiratory burst in macrophage signaling / Am J Respir Crit Care Med 166:S4~S8
Honda S / 1989 / High-performance liquid chromatography of reducing carbohydrates as strongly ultraviolet-absorbing and electrochemically sensitive 1-phenyl-3-methyl-5-pyrazolone derivatives / Anal Biochem 180:351~357
Huang H / 2009 / Distinct patterns of dendritic cell cytokine release stimulated by fungal β-glucans and Toll-like receptor agonists / Infect Immun 77:1774~1781
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