지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 440 - 447 (8page)
- DOI
- 10.5021/ad.2021.33.5.440
이용수
초록· 키워드
오류제보하기
Background Background: Hot springs have been traditionally used as an alternative treatment for a wide range of diseases, including rheumatoid arthritis, bronchial asthma, diabetes, hypertension, psoriasis and atopic dermatitis. However, the clinical effects and therapeutic mechanisms associated with hot springs remain poorly defined.
Objective The purpose of this study was to demonstrate the different effects of hot springs on cellular viability and secretion of inflammatory cytokines on keratinocyte in two geographically representative types of hot springs: NaHCO3-type and NaCl-type, which are the most common types in South Korea.
Methods We performed WST-1, BrdU measurements, human inflammatory cytokine arrays and enzyme-linked immunosorbent assay in HaCaT cells stimulated with toll-like receptor 3 by polyinosinicpolycytidylic acid.
Results The interaction effects of cell viability and cell proliferation were not significantly different regardless of polyinosinic-polycytidylic acid stimulation and cultured hot springs type. Cytokine array and enzymelinked immunosorbent assay analysis showed increased expression of inflammatory cytokines such as interleukin6 and granulocyte-macrophage colony-stimulating factor by polyinosinic-polycytidylic acid stimulation, with expression levels differing according to hot springs hydrochemical composition. Cytokine reduction was not significant.
Conclusion The effects and mechanisms of hot springs treatment in keratinocytes were partially elucidated.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Nasermoaddeli A / 2005 / Balneotherapy in medicine : a review / Environ Health Prev Med 10:171~179
Hashkes PJ / 2002 / Beneficial effect of climatic therapy on inflammatory arthritis at Tiberias Hot Springs / Scand J Rheumatol 31:172~177
Farina S / 2011 / Balneotherapy for atopic dermatitis in children at Comano spa in Trentino, Italy / J Dermatolog Treat 22:366~371
Merial-Kieny C / 2011 / Avène Thermal Spring Water: an active component with specific properties / J Eur Acad Dermatol Venereol 25(Suppl 1):2~5
Castex-Rizzi N / 2011 / Inhibition of TNF-alpha induced-adhesion molecules by Avène Thermal Spring Water in human endothelial cells / J Eur Acad Dermatol Venereol 25(Suppl 1):6~11
Hashkes PJ / 2002 / Beneficial effect of climatic therapy on inflammatory arthritis at Tiberias Hot Springs / Scand J Rheumatol 31:172~177
Farina S / 2011 / Balneotherapy for atopic dermatitis in children at Comano spa in Trentino, Italy / J Dermatolog Treat 22:366~371
Merial-Kieny C / 2011 / Avène Thermal Spring Water: an active component with specific properties / J Eur Acad Dermatol Venereol 25(Suppl 1):2~5
Castex-Rizzi N / 2011 / Inhibition of TNF-alpha induced-adhesion molecules by Avène Thermal Spring Water in human endothelial cells / J Eur Acad Dermatol Venereol 25(Suppl 1):6~11
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