지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives : It has been shown that early intervention is crucial for favorable outcome in patients with schizophrenia. However, development of biomarkers for predicting prognosis of psychotic disorder still requires more research. In this study, we aimed to investigate whether baseline mismatch negativity (MMN) predict prognosis in patients with first episode psychosis (FEP).
Methods : Twenty-four patients with FEP and matched healthy controls (HCs) were examined with MMN at baseline, and their clinical status were re-assessed after 1 year. Repeated-measures analysis of variance was performed to compare baseline MMN between the two groups. Multiple regression analysis was used to identify factors predicting prognosis in FEP patients during the follow-up period.
Results : MMN amplitudes at baseline were significantly reduced in patients with FEP compared to healthy controls. In the multiple regression analysis, baseline MMN amplitude significantly predicted later improvement of performances on digit span and delayed recall of California Verbal Learning Test. However, baseline MMN did not predicted improvement of clinical symptoms.
Conclusion : These results indicate that MMN may be a possible predictor of improvement in cognitive functioning in patients with FEP. Future study with larger sample and longer follow-up period would be needed to confirm the findings of the current study.
목차
등록된 정보가 없습니다.
참고문헌 (54)
참고문헌 신청
McGrath J / 2004 / A systematic review of the incidence of schizophrenia: the distribution of rates and the influence of sex, urbanicity, migrant status and methodology / BMC Med 2:1~13
Edwards J / 2002 / Duration of untreated psychosis (DUP) and outcome in schizophrenia / Psychol Med 32:563~564
Ito S / 2015 / Differential impacts of duration of untreated psychosis (DUP)on cognitive function in first-episode schizophrenia according to mode of onset / Eur Psychiatry 30:995~1001
Yuksel C / 2012 / Gray matter volume in schizophrenia and bipolar disorder with psychotic features / Schizophr Res 138:177~182
Horan WP / 2012 / Social cognition in schizophrenia, Part 2: 12-month stability and prediction of functional outcome in first-episode patients / Schizophr Bull 38:865~872
Edwards J / 2002 / Duration of untreated psychosis (DUP) and outcome in schizophrenia / Psychol Med 32:563~564
Ito S / 2015 / Differential impacts of duration of untreated psychosis (DUP)on cognitive function in first-episode schizophrenia according to mode of onset / Eur Psychiatry 30:995~1001
Yuksel C / 2012 / Gray matter volume in schizophrenia and bipolar disorder with psychotic features / Schizophr Res 138:177~182
Horan WP / 2012 / Social cognition in schizophrenia, Part 2: 12-month stability and prediction of functional outcome in first-episode patients / Schizophr Bull 38:865~872
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