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논문 기본 정보

자료유형
학술저널
저자정보
Takeshi Mochizuki (Department of Orthopedic Surgery Kamagaya General Hospital Chiba Japan) Koichiro Yano (Department of Orthopedic Surgery Tokyo Women's Medical University Tokyo Japan) Katsunori Ikari (Department of Orthopedic Surgery School of Medicine Tokyo Women’s Medical University Tokyo Japan) Ken Okazaki (Department of Orthopedic Surgery Tokyo Women's Medical University Tokyo Japan)
저널정보
대한골다공증학회 Osteoporosis and Sarcopenia Osteoporosis and Sarcopenia Vol.7 No.3
발행연도
2021.9
수록면
110 - 114 (5page)
DOI
10.1016/j.afos.2021.08.001

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Objectives: To investigate effects of romosozumab treatment on disease activity and bone mineral density (BMD) in patients with rheumatoid arthritis (RA) and severe osteoporosis in comparison with effects of denosumab treatment. Methods: A total of 50 women were enrolled in this study. The subjects were randomized equally into 2 groups: the romosozumab group or the denosumab group. Disease activity score in 28 joints (DAS28)- erythrocyte sedimentation rate (ESR) and BMD at lumbar spine were evaluated. Results: The percent changes (Δ) in the BMD values at 3 and 6 months for the lumbar spine were as follows: romosozumab; 4.9% and 5.2%, denosumab: 2.3% and 3.2%. The ΔBMD for the lumbar spine at 3 months was significantly higher in the romosozumab group than in the denosumab group (P= 0.044). The DAS28-ESR at baseline, 3 and 6 months in the romosozumab group were 2.88, 2.60 (P = 0.427) and 2.58 (P = 0.588), respectively. The change from baseline in DAS28-ESR did not differ significantly between these 2 groups at any time point. Conclusions: The present study revealed that romosozumab treatment is more effective than denosumab treatment in increasing BMD of the lumbar spine at 3 months. Furthermore, the present study suggested that romosozumab treatment has no effects on the disease activity of RA in patients with RA and severe osteoporosis for 6 months.

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