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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 151 - 156 (6page)
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The purpose of this study was to determine whether the Ca<sup>2+</sup> signaling pathway is involved in the ability of osteoprotegerin (OPG) to inhibit osteoclast differentiation and maturation. RAW264.7 cells were incubated with macrophage colony-stimulating factor (M-CSF) + receptor activator of nuclear factor-B ligand (RANKL) to stimulate osteoclastogenesis and then treated with different concentrations of OPG, an inhibitor of osteoclast differentiation. The intracellular Ca<sup>2+</sup> concentration [Ca<sup>2+</sup>]i and phosphorylation of Ca<sup>2+</sup>/calmodulin-dependent protein kinase II (CaMKII) in the different treatment groups were measured by flow cytometry and Western blotting, respectively. The results confirmed that M-CSF + RANKL significantly increased [Ca<sup>2+</sup>]i and CaMKII phosphorylation in osteoclasts (p ＜ 0.01), and that these effects were subsequently decreased by OPG treatment. Exposure to specific inhibitors of the Ca<sup>2+</sup> signaling pathway revealed that these changes varied between the different OPG treatment groups. Findings from the present study indicated that the Ca<sup>2+</sup> signaling pathway is involved in both the regulation of osteoclastogenesis as well as inhibition of osteoclast differentiation and activation by OPG.
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