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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Bone homeostasis is maintained by a balance in the levels of osteoclast and osteoblast activity. Osteoclasts are bone-resorbing cells and have been shown to act as key players in various osteolytic diseases. Osteoclasts differentiate from monocyte/macrophage lineage cells in the presence of receptor activator of nuclear factor-κB ligand and macrophage colony-stimulating factor. Osteoblasts support osteoclastogenesis by producing several osteoclast differentiation factors. Toll-like receptors (TLRs) are members of the pattern recognition receptor family that are involved in recognizing pathogen-associated molecular patterns and damage-associated molecular patterns in response to pathogen infection. TLRs regulate osteoclastogenesis and bone resorption through either the myeloid differentiation primary response 88 or the Toll/interleukin-1 receptor domain containing adapter-inducing interferon-β signaling pathways. Since osteoclasts play a central role in the progression of osteolytic diseases, extensive research focusing on TLR downstream signaling in these cells should be conducted to advance the development of effective TLR modulators. In this review, we summarize the currently available information on the role of TLRs in osteoclast differentiation and osteolytic diseases.
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참고문헌 (84)
참고문헌 신청
Mone Zaidi / 2007 / Skeletal remodeling in health and disease / Nature Medicine 13(7):791~801
G. A. Rodan / 2000 / Therapeutic Approaches to Bone Diseases / Science 289(5484):1508~1514
Tatsuo Suda / 1999 / Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families / Endocrine Reviews 20(3):345~357
William J. Boyle / 2003 / Osteoclast differentiation and activation / Nature 423(6937):337~342
H Kodama / 1991 / Essential role of macrophage colony-stimulating factor in the osteoclast differentiation supported by stromal cells. / Journal of Experimental Medicine 173(5):1291~1294
G. A. Rodan / 2000 / Therapeutic Approaches to Bone Diseases / Science 289(5484):1508~1514
Tatsuo Suda / 1999 / Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families / Endocrine Reviews 20(3):345~357
William J. Boyle / 2003 / Osteoclast differentiation and activation / Nature 423(6937):337~342
H Kodama / 1991 / Essential role of macrophage colony-stimulating factor in the osteoclast differentiation supported by stromal cells. / Journal of Experimental Medicine 173(5):1291~1294
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