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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.3
- 수록면
- 251 - 258 (8page)
- DOI
- 10.14348/molcells.2015.2302
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초록· 키워드
오류제보하기
Germline mutations in the breast cancer type 2 susceptibility gene (BRCA2) are linked to familial breast cancer and the progressive bone marrow failure syndrome Fanconi anaemia. Established Brca2 mouse knockout models show embryonic lethality, but those with a truncating mutation at the C-terminus survive to birth and develop thymic lymphoma at an early age. To overcome early lethality and investigate the function of BRCA2, we used T cell-specific conditional Brca2 knockout mice, which were previously shown to develop thymic lymphoma at a low penetrance. In the current study we showed that the number of peripheral T cells, particularly naive pools, drastically declined with age. This decline was primarily ascribed to improper peripheral maintenance. Furthermore, heterozygous mice with one wild-type Brca2 allele manifested reduced T cell numbers, suggesting that Brca2 haploinsufficiency might also result in T cell loss. Our study reveals molecular events occurring in Brca2-deficient T cells and suggests that both heterozygous and homozygous Brca2 mutation may lead to dysfunction in T cell populations.
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참고문헌 (47)
참고문헌 신청
Alter, B. P. / 2003 / Cancer in Fanconi anemia / Blood 101:2072
Bennett, L. M. / 2000 / BRCA2-null embryonic survival is prolonged on the BALB/c genetic background / Mol. Carcinog 28:174~183
Callens, N. / 2002 / Genomic organization and expression of the mouse Brca2 gene / Mamm. Genome 13:352~358
Cheung, A. M. / 2002 / Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis / Cancer Res 62:6194~6204
Cheung, A. M. / 2004 / Brca2deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-)mutant mice / Cancer Res 64:1959~1965
Bennett, L. M. / 2000 / BRCA2-null embryonic survival is prolonged on the BALB/c genetic background / Mol. Carcinog 28:174~183
Callens, N. / 2002 / Genomic organization and expression of the mouse Brca2 gene / Mamm. Genome 13:352~358
Cheung, A. M. / 2002 / Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis / Cancer Res 62:6194~6204
Cheung, A. M. / 2004 / Brca2deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-)mutant mice / Cancer Res 64:1959~1965
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