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논문 기본 정보

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학술저널
저자정보
Do Young Kim (Department of Internal Medicine Yonsei University College of Medicine) Bao Nguyen Toan (Clinical Pathology Department Medic Center Ho Chi Minh) Chee-Kiat Tan (Department of Gastroenterology and Hepatology Singapore General Hospital) Irsan Hasan (Faculty of Medicine University Indonesia/Ciptomangunkusumo Hospital Jakarta) Lyana Setiawan (Clinical Pathology Department Integrated Laboratory Dharmais National Cancer Hospital Jakarta) Ming-Lung Yu (Hepatobiliary Division Department of Internal Medicine Kaohsiung Medical University Hospital; College of Medicine Kaohsiung Medical University Kaohsiung Taiwan; School of Medicine College of Medicine) Namiki Izumi (Japanese Red Cross Musashino Hospital Musashino) Nguyen Nguyen Huyen (National Hospital for Tropical Diseases Hanoi) Pierce Kah-Hoe Chow (Department of Hepato-pancreato-biliary and Transplant Surgery National Cancer Center Singapore and Singapore General Hospital Singapore; Surgery Academic Clinical Program Duke-NUS Medical School Singa) Rosmawati Mohamed (University Malaya Medical Centre Kuala Lumpur) Stephen Lam Chan (State Key Laboratory of Oncology in South China Department of Clinical Oncology The Chinese University of Hong Kong) Tawesak Tanwandee (Department of Medicine Faculty of Medicine Siriraj Hospital Mahidol University Bangkok) Teng-Yu Lee (Department of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan; Department of Medicine School of Medicine Chung Shan Medical University Taichung) Thi Thanh Nguyen Hai (National Hospital for Tropical Diseases Hanoi) Tian Yang (Eastern Hepatobiliary Surgery Hospital Second Military Medical University (Navy Medical University) Shanghai) Woochang Lee (Department of Laboratory Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Henry Lik Yuen Chan (Department of Internal Medicine The Chinese University of Hong Kong and Union Hospital)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제29권 제2호
발행연도
2023.4
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277 - 292 (16page)

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Even though the combined use of ultrasound (US) and alpha-fetoprotein (AFP) is recommended for the surveillance of hepatocellular carcinoma (HCC), the utilization of AFP has its challenges, including accuracy dependent on its cut-off levels, degree of liver necroinflammation, and etiology of liver disease. Though various studies have demonstrated the utility of protein induced by vitamin K absence II (PIVKA-II) in surveillance, treatment monitoring, and predicting recurrence, it is still not recommended as a routine biomarker test. A panel of 17 experts from Asia-Pacific, gathered to discuss and reach a consensus on the clinical usefulness and value of PIVKA-II for the surveillance and treatment monitoring of HCC, based on six predetermined statements. The experts agreed that PIVKA-II was valuable in the detection of HCC in AFP-negative patients, and could potentially benefit detection of early HCC in combination with AFP. PIVKA-II is clinically useful for monitoring curative and intra-arterial locoregional treatments, outcomes, and recurrence, and could potentially predict microvascular invasion risk and facilitate patient selection for liver transplant. However, combining PIVKA-II with US and AFP for HCC surveillance, including small HCC, still requires more evidence, whilst its role in detecting AFP-negative HCC will potentially increase as more patients are treated for hepatitis-related HCC. PIVKA-II in combination with AFP and US has a clinical role in the Asia-Pacific region for surveillance. However, implementation of PIVKA-II in the region will have some challenges, such as requiring standardization of cut-off values, its cost-effectiveness and improving awareness among healthcare providers.
#PIVKA-II #Alpha-fetoprotein #Carcinoma #hepatocellular #Consensus #Biomarkers

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