지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.1
- 수록면
- 82 - 90 (9page)
- DOI
- https://doi.org/10.4111/icu.20220254
이용수
초록· 키워드
오류제보하기
Purpose: Urolithiasis is a common urinary tract disease with growing prevalence. Alpha1-adrenoceptors (α1-ARs) are abundant in ureteral smooth muscle, distributed with different α1-AR subtypes. α1D-AR is the most widely distributed in the ureter. However, the effect of α1D-AR blockade on ureteric contraction remains unknown.
Materials and Methods: We dissected smooth muscle tissues (3 mm×3 mm) from the rat bladder and human ureter, tied silk strips on both tissue ends, and measured contraction in an organ bath chamber. Contraction activity in ureteral smooth muscle cells (USMCs) was immunocytochemically examined using primary rat and human USMC cultures.
Results: Using the organ bath system, we determined the inhibitory effects of silodosin, tamsulosin, and naftopidil. Naftopidil significantly decreased contractility of rat bladder tissue; similar results were observed in human ureteral tissue. To confirm ex vivo experimental results in vitro , we examined the phosphorylation of myosin light chain (MLC), a marker of contractility, in a primary human USMC culture. The examined drugs decreased phospho-MLC levels in human USMCs; however, naftopidil profoundly increased MLC dephosphorylation.
Conclusions: We studied the effects of naftopidil, an α1D-AR inhibitor, on the ureter. Compared with alpha-blockers, naftopidil significantly relaxed ureteral smooth muscle. Therefore, naftopidil could be an effective therapy for patients with ureteral stones.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
In Vitro Effects of Plasma Collected From Rats Administered Naftopidil on Whole Urinary Bladder Preparation Isolated From Rats
International Neurourology Journal
2019 .01
-
Add-on Therapy With the α-Blockers Tamsulosin and Naftopidil Improves Voiding Function by Enhancing Neuronal Activity in Prostatic Hyperplasia Rats
International Neurourology Journal
2018 .01
-
Characterization on Responsiveness of Excitatory Synaptic Transmissions to α1-Adrenoceptor Blockers in Substantia Gelatinosa Neurons Isolated From Lumbo-Sacral Level in Rat Spinal Cords
International Neurourology Journal
2019 .01
-
Effects of High Concentrations of Naftopidil on Dorsal Root- Evoked Excitatory Synaptic Transmissions in Substantia Gelatinosa Neurons In Vitro
International Neurourology Journal
2018 .01
-
Differential Effects of Alpha 1-Adrenoceptor Antagonists on the Postsynaptic Sensitivity: Using Slice Patch-Clamp Technique for Inhibitory Postsynaptic Current in Substantia Gelatinosa Neurons From Lumbosacral Spinal Cord in Rats
International Neurourology Journal
2020 .01
-
Effects of Combination Treatment of Alpha 1-Adrenergic Receptor Antagonists on Voiding Dysfunction: Study on Target Organs in Overactive Bladder Rats
International Neurourology Journal
2016 .01
-
Clinical Efficacy and Safety of Naftopidil Treatment for Patients with Benign Prostatic Hyperplasia and Hypertension: A Prospective, Open-Label Study
Yonsei Medical Journal
2017 .07
-
Robotic ureter reconstruction using the native ureter to treat long-segment ureteral stricture of the transplant kidney utilizing Indocyanine green: The first Korean experience
Investigative and Clinical Urology
2023 .03
-
Postoperative ureteral obstruction after endoscopic treatment for vesicoureteral reflux
Investigative and Clinical Urology
2015 .01
-
Ureteral stenting can be a negative predictor for successful outcome following shock wave lithotripsy in patients with ureteral stones
Investigative and Clinical Urology
2016 .01
-
Emotional Stress Facilitates Micturition Reflex: Possible Inhibition by an α1-Adrenoceptor Blocker in the Conscious and Anesthetized State
International Neurourology Journal
2019 .01
-
A computational model of ureteral peristalsis and an investigation into ureteral reflux
Biomedical Engineering Letters (BMEL)
2018 .01
-
Efficacy and Safety of Naftopidil in Patients With Neurogenic Lower Urinary Tract Dysfunction: An 8-Week, Active-Controlled, Stratified-Randomized, Double-Blind, Double-Dummy, Parallel Group, Noninferiority, Multicenter Design
International Neurourology Journal
2020 .01
-
Risk Factors of Febrile Urinary Tract Infection after Ureteral Reimplantation in Infant
Urogenital Tract Infection
2020 .01
-
Evaluation of the ureteral jet in dogs by using color Doppler ultrasonography
Journal of Veterinary Science
2017 .09
-
Clinical Characteristics of Ureteral Duplication in Children
Childhood Kidney Diseases
2019 .01
-
The Inhibitory Mechanism on Acetylcholine-Induced Contraction of Bladder Smooth Muscle in the Streptozotocin-Induced Diabetic Rat
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
The Gachon University Ureteral Narrowing score: A comprehensive standardized system for predicting necessity of ureteral dilatation to treat proximal ureteral calculi
Investigative and Clinical Urology
2016 .01
-
The Gachon University Ureteral Narrowing score: A comprehensive standardized system for predicting necessity of ureteral dilatation to treat proximal ureteral calculi
Investigative and Clinical Urology
2016 .01
-
Ureteral stricture formation after ureteroscope treatment of impacted calculi: A prospective study
Investigative and Clinical Urology
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0