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논문 기본 정보

자료유형
학술저널
저자정보
Hyun Hwangbo (Dong-eui University College of Korean Medicine) Hee-Jae Cha (Kosin University College of Medicine) Min Yeong Kim (Dong-eui University College of Korean Medicine) Seon Yeong Ji (Dong-eui University College of Korean Medicine) Da Hye Kim (Dong-eui University College of Korean Medicine) Jeong Sook Noh (Tongmyong University) Tae Hee Kim (Hamsoapharm Central Research) Heui-Soo Kim (Pusan National University) Sung-Kwon Moon (Chung-Ang University) Gi-Young Kim (Jeju National University) Yung Hyun Choi (Dong-eui University College of Korean Medicine)
저널정보
대한지역사회영양학회 Nutrition Research and Practice Nutrition Research and Practice Vol.18 No.6
발행연도
2024.12
수록면
793 - 805 (13page)

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BACKGROUND/OBJECTIVES: Recently, herbal medicines have gained attention for the treatment of benign prostatic hyperplasia (BPH), a common disease in elderly men. In this study, we aimed to determine the effect of ethanol extract of Asparagi radix (EAR), which is traditionally used to treat various diseases, on BPH development using a testosterone- induced BPH model.
MATERIALS/METHODS: Testosterone propionate (TP)-treated Sprague–Dawley rats were used to establish a BPH model in vivo. EAR was orally administered along with TP, and finasteride was used as a positive control. All rats were sacrificed at the end of the experiment, and pathological changes in the prostate tissue and levels of key biomarkers associated with BPH pathogenesis were assessed.
RESULTS: Oral administration of EAR significantly inhibited TP-induced BPH by reducing the prostate weight, lumen size, and epithelial thickness in a concentration-dependent manner. EAR also significantly abrogated the expression of 5α-reductase type 2 (SRD5A2), proliferating cell nuclear antigen, and prostate-specific antigen (PSA) induced by TP. Additionally, serum levels of testosterone, dihydrotestosterone, and PSA were elevated in the TP-induced group but decreased in the EAR-treated group. EAR also decreased the expression levels of the androgen receptor (AR) and its coactivators in TP-induced BPH model rats.
CONCLUSION: Our findings revealed that EAR protected against BPH by inhibiting 5α-reductase activity and AR signaling pathway, suggesting its potential for BPH treatment.

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ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

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