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자료유형
학술저널
저자정보
Hyun Hwangbo (Dongeui University) Da He Kwon (Dongeui University) Eun Ok Choi (Dongeui University) Min Yeong Kim (Dongeui University) Kyu Im Ahn (Dongeui University) Seon Yeong Ji (Dongeui University) Jong Sik Kim (Kosin University College of Medicine) Kyung-Il Kim (Gurye Sansooyu Farming Association Corporation) No-Jin Park (Gurye-gun Agricultural Center) Bum Hoi Kim (Dongeui University College of Korean Medicine) Gi-Young Kim (Jeju National University) Su-Hyun Hong (Dongeui University) Cheol Park (Dongeui University) Ji-Suk Jeong (Gurye-gun Agricultural Center) Yung Hyun Choi (Dongeui University)
저널정보
한국영양학회 Nutrition Research and Practice Nutrition Research and Practice Vol.12 No.5
발행연도
2018.10
수록면
378 - 386 (9page)

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BACKGROUND/OBJECTIVES: Benign prostatic hypertrophy (BPH) is a major cause of abnormal overgrowth of the prostate mainly in the elderly. Corni Fructus has been reported to be effective in the prevention and treatment of various diseases because of its strong antioxidant effect, but its efficacy against BPH is not yet known. This study was designed to evaluate the therapeutic efficacy of Corni Fructus water extract (CF) in testosterone-induced BPH rats.
MATERIALS/METHODS: To induce BPH, rats were intraperitoneal injected with testosterone propionate (TP). Rats in the treatment group were orally administered with CF with TP injection, and finasteride, which is a selective inhibitor of 5α-reductase type 2, was used as a positive control.
RESULTS: Our results showed that the increased prostate weight and histopathological changes in BPH model rats were suppressed by CF treatment. CF, similar to the finasteride-treated group, decreased the levels of testosterone and dihydrotestosterone by TP treatment in the serum, and it also reduced 5α-reductase expression and concentration in prostate tissue and serum, respectively. In addition, CF significantly blocked the expression of the androgen receptor (AR), AR co-activators, and proliferating cell nuclear antigen in BPH rats, and this blocking was associated with a decrease in prostate-specific antigen levels in serum and prostate tissue.
CONCLUSIONS: These results suggest that CF may weaken the BPH status through the inactivation of at least 5α-reductase and AR activity and may be useful for the clinical treatment of BPH.

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INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

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