지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.12
- 수록면
- 247 - 254 (8page)
- DOI
- 10.22889/KJP.2024.55.4.247
이용수
초록· 키워드
오류제보하기
Scirpus planiculmis (SP) has been used for a long time as a traditional therapy to cure bronchiectasis, gynecopathy, chest pain, and dyspepsia in Asian countries. However, the therapeutic effect of SP on allergic diseases remains to be determined. In this study, we observed the anti-allergic effect and its mechanism of SP in mast cells and mice. SP significantly suppressed the degranulation and expression of tumor necrosis factor-α (TNF-α) and interleukin-4 (IL-4) in mast cells stimulated by antigen, and its inhibition was reversible. Mechanistically, SP inhibited the activation of spleen tyrosine kinase (Syk) by antigen and its downstream signaling proteins such as linker for activation of T cell (LAT), phospholipase Cγ (PLCγ), Akt, and mitogen activated protein (MAP) kinases, including ERK, JNK, and p38, in a dose-dependent manner. In mice, SP significantly inhibited the passive cutaneous anaphylaxis (PCA) reaction and degranulation of mast cells in ear tissue by antigen. Taken together, SP suppressed the allergic response by antigen in mice via the inhibition of Syk activation in mast cells, which warrants further investigation for developing anti-allergic herbal medicine.
목차
Abstract
Materials and Methods
Results
Discussion
Conclusions
References
참고문헌 (46)
참고문헌 신청
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Pawanker, R., Canonica, G. W., Holgate, S. T. and Lockey, R. F. (2011) World Allergy Organization (WAO) White Book on Allergy.
Urb, M. and Sheppard, D. C. (2012) The role of mast cells in the defense against pathogens. PLoS Pathog. 8: e1002619.
Metcalfe, D. D., Baram, D. and Mekori, Y. A. (1997) Mast cells. Physiol. Rev. 77: 1033-1079.
Asher, M. I., Montefort, S., Bjorksten, B., Lai, C. K., Strachan, D. P., Weiland, S. K., Williams, H. (2006) Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC phases one and three repeat multicountry cross-sectional surveys. Lancet 368: 733-743.
Pawanker, R., Canonica, G. W., Holgate, S. T. and Lockey, R. F. (2011) World Allergy Organization (WAO) White Book on Allergy.
Urb, M. and Sheppard, D. C. (2012) The role of mast cells in the defense against pathogens. PLoS Pathog. 8: e1002619.
Metcalfe, D. D., Baram, D. and Mekori, Y. A. (1997) Mast cells. Physiol. Rev. 77: 1033-1079.
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