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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.6
- 수록면
- 87 - 93 (7page)
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The effect of ginsenoside-Rb2, one of a major pharmacological component of Panax ginseng c.A. Meyer. on low density lipoprotein (LDL) receptor expression was investigated and compared with hypocholesterolemic dl1lg lovastatin. In HepG2 cell. exogenous cholesterol decreased LDL receptor mRNA expression, but ginsenoside-Rb2 recovered this reduction of LDL receptor mRNA up to normal expression level. Lovastatin also increased LDL receptor mRNA expression as similar as ginsenoside-Rb2 did. The reduction of sterol regulatory element binding protein (SREBP) transcription by exogenous cholesterol was also similarly recovered by ginsenoside-Rb2 and lovastatin addition. Compound K, a metabolite of ginsenoside-Rb2 and -Rb I by human intestinal bacteria also increased the SREBP mRNA expression in cholesterol-enriched condition. Ginsenoside-Rb2 seems to up-regulate LDL receptor mRNA expression through the induction of de 1101'0 SREBP transcription. Therefore. increased expression of SREBP mRNA by ginsenoside-Rb2 elevated the LDL receptor mRNA expression in HepG2 cells. and these inductions possibly drop the plasma cholesterol level in hypercholesterolemia patients. ill vivo, as likely in case of lovastatin.
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논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
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인삼의 총사포닌 , Ginsenoside-Rb_1_ , Ginsenoside-Rb_2_ 와 Lovastation에 의한 Hep G2 세포의 HMG CoA Reductase 및 LDL수용체 mRNA 발현 유발효과의 비교 ( Comparison of the Effects of Ginseng Total Saponin , Ginsenoside-Rb_1_ , Ginsenoside-Rb_2_ and Lovastatin on the Expression of mRNAs for HMG CoA Reductase and LDL Receptor )
Journal of Ginseng Research
1996 .12
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Ginsenoside Rb2 Upregulates the Low Density Lipoprotein Receptor Gene Expression through the Activation of the Sterol Regulated Element Binding Protein Maturation in HepG2 Cells
Journal of Ginseng Research
2005 .12
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Conversion of Ginsenoside Rb1, Rb2, and Rc to Minor Ginsenoside by Acid Treatment
고려인삼학회 학술대회
2009 .05
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Ginsenosides Rb2 Protects High Glucose-Induced Apoptosis in ARPE cells
Laboratory Animal Research
2008 .03
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$\beta$-Glucosidases of human intestinal bacteria transforming ginsenoside Rb1 and Rb2 to compound K
대한약학회 학술대회
2000 .01
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Enzymatic formation of compound-K from ginsenoside Rb1 by enzyme preparation from cultured mycelia of Armillaria mellea
Journal of Ginseng Research
2016 .04
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Effects of in vitro immune stimulation by ginsenoside Rb1
고려인삼학회 학술대회
2006 .05
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Biotransformation of major ginsenosides in ginsenoside model culture by lactic acid bacteria
Journal of Ginseng Research
2017 .01
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Rapid and Simultaneous Determination of Ginsenosides Rb1, Rb2, Rc and Re in Korean Red Ginseng Extract by HPLC using Mass/Mass Spectrometry and UV Detection
Journal of Ginseng Research
2008 .12
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Identification of NMR Data for Diol-saponins of Panax ginseng, Ginsenosides Rb₁, Rb₂, Rc, and Rd
고려인삼학회 학술대회
2009 .12
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Ginsenoside Rb2 suppresses the glutamate-mediated oxidative stress and neuronal cell death in HT22 cells
Journal of Ginseng Research
2019 .04
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Pharmacokinetics of ginsenoside Rb1 and its metabolite compound K after oral administration of Korean Red Ginseng extract
Journal of Ginseng Research
2013 .10
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Protective effect of ginsenoside-Rb2 from Korean red ginseng on the lethal infection of haemagglutinating virus of Japan in mice
Journal of Ginseng Research
2013 .01
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Protective Effect of Ginsenoside Rb₁ on Hydrogen Peroxide-induced Oxidative Stress in Rat Articular Chondrocytes
Journal of Ginseng Research
2012 .04
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Inhibitory Effects of Ginsenoside Rb₁ on Atopic Dermatitis-Like Skin Lesions in Mice
Journal of Ginseng Research
2010 .12
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Epidermis Proliferative Effect of the Panax ginseng Ginsenoside $Rb_2$
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2002 .01
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A novel hair follicle cell regulator : ginsenoside Rd and Rb₁
고려인삼학회 학술대회
2011 .04
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Proteomic analysis reveals that the protective effects of ginsenoside Rb1 are associated with the actin cytoskeleton in β-amyloid-treated neuronal cells
Journal of Ginseng Research
2016 .07
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Enzymatic Transformation of Ginsenoside Rb1 by Lactobacillus pentosus Strain 6105 from Kimchi
Journal of Ginseng Research
2012 .07
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