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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 227 - 230 (4page)
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초록· 키워드
오류제보하기
Compounds of polyketide origin possess a wealth of pharmacological effects, including antibacterial, antifungal, antiparasitic, anticancer and immunosuppressive activities. Many of these compounds and their semisynthetic derivatives are used today in the clinic. Most of the gene clusters encoding commercially important drugs have also been cloned and sequenced and their biosynthetic mechanisms studied in great detail. The area of biosynthetic engineering of the enzymes involved in polyketide biosynthesis has recently advanced and been transferred into the industrial arena. In this work, we introduce a computational system to provide the user with a wealth of information that can be utilized for biosynthetic engineering of enzymes involved in post-PKS tailoring steps. Post-PKS tailoring steps are necessary to add functional groups essential for the biological activity and are therefore important in polyketide biosynthesis.
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등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
Altschul, S.F. / 1990 / Basic local alignment search tool / J. Mol. Biol 213:403~410
Faust, B / 2000 / Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717 / Microbiology 146:147~154
Floss, H.G. / 2001 / Antibiotic biosynthesis: from natural to unnatural compounds / J. Ind. Microbiol. Biotechnol 27:183~194
Hopwood, D.A. / 1990 / Molecular genetics of polyketides and its comparison with Fatty acid biosynthesis / Annu. Rev. Genet 24:37~66
Kwan, D.H. / 2008 / Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases / Chem. Biol 15:1231~1240
Faust, B / 2000 / Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717 / Microbiology 146:147~154
Floss, H.G. / 2001 / Antibiotic biosynthesis: from natural to unnatural compounds / J. Ind. Microbiol. Biotechnol 27:183~194
Hopwood, D.A. / 1990 / Molecular genetics of polyketides and its comparison with Fatty acid biosynthesis / Annu. Rev. Genet 24:37~66
Kwan, D.H. / 2008 / Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases / Chem. Biol 15:1231~1240
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