지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.3
- 수록면
- 33 - 39 (7page)
이용수
초록· 키워드
오류제보하기
To validate and to estimate the chemical hazard playa very important role to environment and human health. The detection of many synthetic chemicals including agrochemicals that may pose a genetic hazard in our environment is of great concern at present. Since these substances are not limited to the original products, and enter the environment, they have become widespread environmental pollutants, thus leading to a variety of chemicals that possibly threaten the public health. Pyrazosulfuron-ethyl [Ethyl-5-(4,6-dimethoxypyrimidin-2-ylcarbamoylsulfamoyl)-1-methylpyrazole-4-carboxylate, C_(14)H_(18)N_6O_7S, M, W.=414,39, CAS No. 93697-74-6], is one of well known rice herbicide belong in the sulfonyl urea group. To clarify the genotoxicity of this agrochemical, Ames bacterial reversion assay, in vitro chromosomal aberration assay with Chinese hamster lung (CHL) fibroblast and bone marrow micronucleus assay in mice were subjected. In Ames assay, although pyrazosulfuron-ethyl revealed cytotoxic at 5,000-140 ㎍/plate in Salmonella typhimurium TA100, no dose-dependent mutagenic potential in 4.4~70 ㎍/plate of S. typhimurium TA 98, TA 100, TA1535 and TA 1537 both in thc absence and presence of S-9 metabolic activation system was observed. Using CHL fibroblasts, the 50% cell growth inhibition concentration (IC_(50)) of pyrazosulfuron-ethyl was determined as 1,243 ㎍/mL, and no chromosomal aberration was observed both in the absence and presence of S-9 mixture in the concentration range of 311-1,243 ㎍/mL. And also, in vivo micronucleus assay using mouse bone marrow, pyrazosulfuron-ethyl revealed no remarkable induction of MNPCE (micronucleated polychromatic erythrocytes/l000 polychromatic erythrocytes) in the dose range of 625-2,500 mg/kg body weight when administered orally. Consequently, Ames bacterial gene mutation with Salmonella typhimurium, in vitro chromosome aberration with mammalian cells and in vivo bone marrow micronucleus assay revealed no clastogenic potential of pyrazosulfuron-ethyl in this study.
목차
ABSTRACT
Introduction
Materials and Methods
Results and Discussion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Evaluation of the Genetic Toxicity of Synthetic Chemicals (X) - In vivo Bone Marrow Micronucleus Assay of 17 Synthetic Chemicals In Mice -
한국환경성돌연변이·발암원학회지
2004 .03
-
Toxicity Study on Chinese Herbal Drugs Using the Micronucleus Assay in Murine Bone Marrow Erythrocytes
한국독성학회지
1989 .12
-
Genotoxicity Test on 3,9-Diferuloyl-6-oxopterocarpen, a New Agent Candidate for Anti-aging Material
Laboratory Animal Research
2008 .03
-
Micronucleus Test of Pinella Rhizoma Aqueous Extracts in Bone Marrow Cells of Male ICR Mice - In Vivo Genotoxicity
한국한의학연구원 논문집
2009 .12
-
컴퓨터 이미지 분석법을 이용한 마우스 골수세포에서 소핵의 계수
Toxicological Research
2002 .12
-
HMC05의 경구투여 소핵시험 및 복귀돌연변이 시험
대한본초학회지(본초분과학회지)
2010 .01
-
Aluminum oxide, calcium oxide, sodium tetraborate 처리에 의한 설치류 골수세포의 소핵유발 연구
Environmental Analysis Health and Toxicology
2009 .06
-
Genotoxicity Study of AS6, a Triterpenoid Derivatives
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2003 .01
-
Evaluation of the genetic toxicity of synthetic chemicals (Ⅴ) - in vitro Chromosomal Aberration Assay with 17 chemicals in Chinese Hamster Lung Cells -
한국환경성돌연변이·발암원학회지
2002 .12
-
Chemoprotective Effects of Hesperidin Against Genotoxicity Induced by Cyclophosphamide in Mice Bone Marrow Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
Evaluation of the Genetic Toxicity of Synthetic Chemicals (Ⅲ) - in vitro Chromosomal Aberration Assay with 28 Chemicals in Chinese Hamster Lung Cells -
한국환경성돌연변이·발암원학회지
2001 .03
-
Micronucleus Test of Bupleuri Radix Aqueous Extract in Bone Marrow Cells of Male ICR Mice
한국한의학연구원 논문집
2012 .08
-
Evaluation of the Genetic Toxicity of Synthetic Chemicals (II), a Pyrethroid Insecticide, Fenpropathrin
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1996 .01
-
Evaluation of the Genetic Toxicity of Synthetic Chemicals (Ⅳ) - in vitro Chromosomal Aberration Assay with 18 Chemicals in Chinese Hamster Lung Cells -
한국환경성돌연변이·발암원학회지
2002 .09
-
Micronucleus Test of Picrorrhiza Rhizoma Aqueous Extract in Bone Marrow Cells of Male ICR Mice
Toxicological Research
2011 .06
-
GST 추출물의 유전독성평가
동의생리병리학회지
2014 .12
-
In vivo Micronucleus Assay - Historical Review and Current Improvement
한국환경성돌연변이·발암원학회지
2003 .09
-
INTEGRATION OF MICRONUCLEUS ASSAY INTO GENERAL TOXICITY TESTING FOR 3RS
환경독성보건학회 심포지엄 및 학술대회
2009 .11
-
Studies on the Genetic Toxicity of NP-77A
한국응용약물학회 춘계학술발표논문집
1995 .01
-
Evaluation of Genotoxicity of Water and Ethanol Extracts from Rhus verniciflua Stokes (RVS)
Toxicological Research
2008 .06
이 논문의 저자 정보
이 논문과 함께 이용한 논문
PLC의 성공적 시장정착을 위한 제도적 접근
이정동
,
김태유
,
이용길
전기의세계
2000
.11
MEMS 기반의 IR CO₂ 센서 제작 및 특성 평가
金信槿
,
韓龍熙
,
文盛昱
전기학회논문지 C
2005
.05
동시출현 자질과 집단 지성을 이용한 지식검색 문서 사용자 명성 평가
이현우
,
한요섭
,
김래현
외 1명
인지과학
2008
.12
몬테카를로 시뮬레이션을 이용한 LCI data 불확실성 처리방법론
박지형
,
서광규
Journal of the Korean Society for Precision Engineering
2004
.12
Evaluation of the Genetic Toxicity of Synthetic Chemicals (XIII) - Single Cell Gel Electrophoresis of Benzoyl Chloride, 2-Propyn-1-ol, and 2-Phenoxyethanol in Chinese Hamster Lung Fibroblast -
Jae-Chun Ryu
,
Youn-Jung Kim
한국환경성돌연변이·발암원학회지
2004
.06
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-476-017705472