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자료유형
학술저널
저자정보
저널정보
한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.1 No.1
발행연도
1996.6
수록면
93 - 98 (6page)

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Lipoprotein(a)[Lp(a)] is a macromolecular complex found in human plasma that combines structural elements composed of LDL and apo(a), and that is associated with premature coronary heart disease and stroke. In this study, various samples which consisted of normal and abnormal LDL and Lp(a) were selected for comparison. The above samples were incubated with copper in order to oxidize and to compare atheroma formation, in vitro and free radical formation of Lp(a) was decreased compared to purified LDL. And LDL from a 40 year old donor was higher in the free radical formation than that from a 20 years old donor. In order to investigate the macrophage foam cell formation, oxidized LDL or Lp(a) was incubated with human monocyte derived macrophage(HMDM). Oxidized samples enhanced on acceptability of foam cell formation by HMDM were compared to the control group. Also, structural changes of LDL and Lp(a) against oxidation times were found from HPLC mapping.

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Abstract

INTRODUCTION

MATERIALS AND METHODS

RESULTS AND DISCUSSION

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