지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.4 No.1
- 발행연도
- 1999.3
- 수록면
- 70 - 74 (5page)
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초록· 키워드
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The primary objective of these studies was to screen the materials showing inhibitions of HMG-CoA reductase in vitro. The secondary objective was to determine the effect of garlic, lovastatin and copper on cholesterol concentrations in plasma, liver and breast muscle of pullets. In experiment 1, the degree of inhibition of the selective samples on HMG-CoA reductase activity was determined in vitro. The inhibition rate of water soluble garlic extracts, lovastatin and copper to HMG-CoA reductase activity were 51.3%, 87.5%, and 82.0%, respectively. In experiment 2, control diet (basal diet), garlic powder (3% in diet), lovastatin (300 ㎎/㎏ of diet) and copper (200 ㎎/㎏ of diet) were fed to pullets in order to investigate the changes of cholesterol concentration in plasma and tissues. Plasma total cholesterol, and LDL-cholesterol were significantly reduced in pullets fed a diet containing 3% garlic powder. However, copper significantly increased total cholesterol compared to controls and lovastatin did not affect plasma cholesterol concentration. Total cholesterol in liver and breast muscle in pullets were not affected by adding cholesterol-lowering materials to the diets. The data suggests that it is not easy for HMG-CoA reductase inhibitors to reduce cholesterol levels in the body due to complication in cholesterol metabolism. However, garlic administration can lower the levels of plasma cholesterol in pullets.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
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