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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국식품영양과학회 한국식품영양과학회지 한국식품영양과학회지 제35권 제10호
발행연도
2006.12
수록면
1,363 - 1,370 (8page)

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This study was designed to evaluate the effect of Agaricus blazei β-glucan and egg shell calcium complex on bone metabolism in ovariectomized (OVX) rats. Forty Sprague-Dewley female rats, 10 weeks of age (248±1.7 g), were divided into 4 groups and fed on the experimental diets for 6 weeks: sham operated control treated with normal diet containing 0.5% calcium (Sham-C), OVX-control treated with normal diet containing 0.5% calcium (OVX-C), OVX-β-glucan group treated with β-glucan diet containing 0.5% calcium (OVX-G), and OVX-β-glucan egg shell calcium complex treated with OVX-β-glucan egg shell calcium complex containing 0.5% calcium (OVX-GE). Bone weight of femur was higher in the OVX-GE group than in the other OVX groups. Bone mineral density of femur was significantly different (p<0.05) among the experimental groups and showed the highest level in the OVX-GE group. Calcium absorption rate and retention were higher in the β-glucan supplement groups than in the other groups (p<0.05). Alkaline phosphatase activities and osteocalcin levels of serum showed lower in the β-glucan supplement groups than in the OVX-C group. Deoxypyridinoline crosslink values of urine, indicator of bone absorption, showed the lowest in the OVX-GE group. The β-glucan supplemented groups had a lower bone resorption ratio than in the OVX-C group. We concluded that bioavailability of calcium is higher in β-glucan supplement groups compared to those in OVX rats. From the above results, these findings suggest the possibility of using β-glucan egg shell calcium complex as a functional food material related to bone metabolism, even though there is no significant difference between the groups of β-glucan and β-glucan-egg shell calcium complex supplementation.

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UCI(KEPA) : I410-ECN-0101-2009-511-017608756