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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.11 No.4
- 발행연도
- 2006.12
- 수록면
- 268 - 272 (5page)
이용수
초록· 키워드
오류제보하기
Cimicifugae Rhizoma (CR) belongs to the Ranunculaceae family, which has been traditionally used to treat climacteric complaints, antipyretics and diaphoresis as an alternative medicine for estrogen hormone replacement therapy with estrogens. Recently, it has been reported that different extract fractions of CR have various effects such as anti-allergic, anti-inflammatory and anti-proliferative activities. The current study investigated the immunomodulatory effects of Cimicifugae Rhizoma water extracts (CRE) in the macrophage-like cell line, Raw 264.7. Our results showed that CRE (1～50 ㎍/mL) stimulated tumoricidal activity and NO production, whereas phagocytic activity was inhibited at the same concentrations. Additionally, iNOS mRNA expression was significantly increased in Raw 264.7 exposed to CRE as demonstrated by RT-PCR. These results indicate that the tumoricidal activity induced by CRE may be mediated by the production of NO and these activities may be useful for the treatment of diseases such as cancer.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (20)
참고문헌 신청
Hahn H, Kaufmann SH. 1981. The role of cell-mediated immunity in bacterial infections. Rev Infect Dis 3:1221-1250.
Verstovsek S, Maccubbin D, Ehrke MJ, Mihich E. 1992. Tumoricidal activation of murine resident peritoneal macrophages by interleukin 2 and tumor necrosis factor alpha. Cancer Res 52: 3880-3885.
Adams DO, Hamilton TA. 1984. The cell biology of macrophage activation. Annu Rev Immunol 2: 283-318.
Burleson GR, Dean JH, Munson AE, 1995. Methods in immunotoxicology. Wiley-Liss, New York, USA. Vol 2.
Nathan CF. 1987. Secretory products of macrophages. J Clin Invest 79: 319-326.
Verstovsek S, Maccubbin D, Ehrke MJ, Mihich E. 1992. Tumoricidal activation of murine resident peritoneal macrophages by interleukin 2 and tumor necrosis factor alpha. Cancer Res 52: 3880-3885.
Adams DO, Hamilton TA. 1984. The cell biology of macrophage activation. Annu Rev Immunol 2: 283-318.
Burleson GR, Dean JH, Munson AE, 1995. Methods in immunotoxicology. Wiley-Liss, New York, USA. Vol 2.
Nathan CF. 1987. Secretory products of macrophages. J Clin Invest 79: 319-326.
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UCI(KEPA) : I410-ECN-0101-2009-511-017667484