지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.11 No.4
- 발행연도
- 2006.12
- 수록면
- 273 - 277 (5page)
이용수
초록· 키워드
오류제보하기
Recently, Rhei Rhizoma extracts (RRE) have begun to receive more attention as potential biological response modifiers. In the present study, we studied the antiproliferative effect of RRE on tumor cells and the effect of RRE on macrophage function. A variety of tumor cells and macrophages were treated with RRE at various concentrations. The effect of RRE on cell proliferation was measured by MTT assay and the effect of RRE on the production of nitric oxide (NO) was determined in the macrophage-like cell lines Raw264.7, C6 and peritoneal macrophages (pMQ). RRE inhibited the growth of tumor cells (e.g., B16, HOS). However, the effects of RRE on the production of NO varied with macrophage types. RRE had no effect on C6 cell growth and slightly increased the growth of Raw264.7 cells. In addition, treatment of normal pMQ with RRE enhanced NO production in a concentration-dependent manner, whereas RRE suppressed NO production at 50 ㎍/mL in both Raw264.7 and C6 cells. However, RRE suppressed NO production in LPS/IFN-γ-stimulated C6 cells. Overall, these results suggest that RRE elicits an antiproliferative property and differentially modulates NO production in various macrophages, and have a potential for therapeutic application.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (37)
참고문헌 신청
Torrence PF. 1985. Biological Response Modifiers. Academic Press Inc, p 1-6.
Giaccone G, Schilsky R, Sondel P. 2001. Cancer chemotherapy and biological response modifiers. Elsevier, Amsterdam, Netherlands. Vol 19.
Hahn H, Kaufmann SH. 1981. The role of cell-mediated immunity in bacterial infections. Rev Infect Dis 3: 1221-1250.
Verstovsek S, Maccubbin D, Ehrke MJ, Mihich E. 1992. Tumoricidal activation of murine resident peritoneal macrophages by interleukin 2 and tumor necrosis factor alpha. Cancer Res 52: 3880-3885.
Nathan CF. 1987. Secretory products of macrophages. J Clin Invest 79: 319-326.
Giaccone G, Schilsky R, Sondel P. 2001. Cancer chemotherapy and biological response modifiers. Elsevier, Amsterdam, Netherlands. Vol 19.
Hahn H, Kaufmann SH. 1981. The role of cell-mediated immunity in bacterial infections. Rev Infect Dis 3: 1221-1250.
Verstovsek S, Maccubbin D, Ehrke MJ, Mihich E. 1992. Tumoricidal activation of murine resident peritoneal macrophages by interleukin 2 and tumor necrosis factor alpha. Cancer Res 52: 3880-3885.
Nathan CF. 1987. Secretory products of macrophages. J Clin Invest 79: 319-326.
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