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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.6
- 수록면
- 127 - 133 (7page)
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초록· 키워드
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This study was designed to investigate the effects of high concentration of (-)-epigallocatechin-3-gallate (EGCG) on the neuronal activity of rat substantia nigra dopaminergic neurons. Sprague-Dawley rats aged 14 to 16 days were decapitated under ether anesthesia. After treatment with pronase and thermolysin, the dissociated dopaminergic neurons were transferred into a chamber on an inverted microscope. Spontaneous action potentials and potassium currents were recorded by standard patch-clamp techniques under current and voltage-clamp modes respectively. 18 dopaminergic neurons (80%) revealed inhibitory responses to 40 and 100 μM of EGCG and 4 neurons (20%) did not respond to EGCG. The spike frequency and resting membrane potential of these cells were decreased by EGCG. The amplitude of afterhyperpolarization was increased by EGCG. Whole potassium currents of dopaminergic neurons were increased by EGCG (n=10). These experimental results suggest that high concentration EGCG decreases the neuronal activity of the dopaminergic neurons by altering the resting membrane potential and afterhyperpolarization.
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서론
재료 및 방법
결과
고찰
감사의 글
REFERENCES
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Bae JH / 2002 / EGCG attenuates AMPA-induced intracellular calcium increase in hippocampal neurons / Biochem Biophys Res Commun 290 : 1506 ~ 1512
2. [학술지(정기간행물)] - Blum D / 2001 / Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease / Prog Neurobiol 65 : 135 ~ 172
3. [학술지(정기간행물)] - Campos-Toimil M / 2007 / Effects of (-)-epigallocatechin-3-gallate in Ca2+-permeable non-selective cation channels and voltage-operated Ca2+ channels in vascular smooth muscle cells / Life Sci 80 : 2147 ~ 2153
4. [학술지(정기간행물)] - Cordey M / 2003 / Estrogen activates protein kinase C in neurons: role in neuroprotection / J Neurochem 84 : 1340 ~ 1348
5. [학술지(정기간행물)] - Deng HM / 2008 / Effects of EGCG on voltage-gated sodium channels in primary cultures of rat hippocampal CA1 neurons / Toxicology 252 : 1 ~ 8
2. [학술지(정기간행물)] - Blum D / 2001 / Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease / Prog Neurobiol 65 : 135 ~ 172
3. [학술지(정기간행물)] - Campos-Toimil M / 2007 / Effects of (-)-epigallocatechin-3-gallate in Ca2+-permeable non-selective cation channels and voltage-operated Ca2+ channels in vascular smooth muscle cells / Life Sci 80 : 2147 ~ 2153
4. [학술지(정기간행물)] - Cordey M / 2003 / Estrogen activates protein kinase C in neurons: role in neuroprotection / J Neurochem 84 : 1340 ~ 1348
5. [학술지(정기간행물)] - Deng HM / 2008 / Effects of EGCG on voltage-gated sodium channels in primary cultures of rat hippocampal CA1 neurons / Toxicology 252 : 1 ~ 8
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UCI(KEPA) : I410-ECN-0101-2009-510-018446113