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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.14 No.4
- 발행연도
- 2009.12
- 수록면
- 269 - 276 (8page)
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초록· 키워드
오류제보하기
Overproduction of reactive oxygen species (ROS), including nitric oxide (NO), could be associated with the pathogenesis of various diseases such as cancer and chronic inflammation. Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) are known to play key roles in the development of these diseases. Cedrela sinensis leaves have been used in Asian countries as a traditional remedy for enteritis, dysentery and itching. In the present study, we investigated the anti-inflammatory effects of Cedrela sinensis leaves in lipopolysaccharide (LPS)- stimulated RAW 264.7 macrophages. Powder of C. sinensis leaves was extracted with 95% ethanol and fractionated with a series of organic solvents including n-hexane, dichloromethane, ethyl acetate, n-butanol, and water. The dichloromethane (DCM) fraction strongly inhibited NO production possibly by down-regulating iNOS and COX-2 expression, as determined by Western blotting. Hydrogen peroxide-induced generation of reactive oxygen species (ROS) was also effectively inhibited by the DCM fraction from C. sinensis leaves. In addition, C. sinensis inhibited LPS-mediated p65 activation via the prevention of IκB-α phosphorylation. Furthermore, mitogen-activated protein kinases (MAPKs) such as ERK 1/2 and p38 were found to affect the expression of iNOS and COX-2 in the cells. Taken together, our data suggest that leaves of C. sinensis could be used as a potential source for anti-inflammatory agents.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (44)
참고문헌 신청
1. [단행본] - LI P / 1980 / Medicinal plants of East and Southeast Asia; attributed properties and uses / MIT press, Cambridge, USA : 264 ~
2. [단행본] - Ga S / 1911 / Chinese material medica, vegetable kingdom / American presbyterian mission press, Shanghai, China. : 100 ~
3. [학술지(정기간행물)] - Mitsui K / 2004 / Limonoids from Cedrela sinensis / Phytochemistry : 3075 ~ 3081
4. [학술지(정기간행물)] - Luo XD / 2000 / Limonoids and phytol derivatives from Cedrela sinensis / Fitoterapia : 492 ~ 496
5. [학술지(정기간행물)] - Park JC / 1994 / Studies on the chemical components and biological activities of edible plants in Korea / J Korean Soc Food Nutr : 116 ~ 119
2. [단행본] - Ga S / 1911 / Chinese material medica, vegetable kingdom / American presbyterian mission press, Shanghai, China. : 100 ~
3. [학술지(정기간행물)] - Mitsui K / 2004 / Limonoids from Cedrela sinensis / Phytochemistry : 3075 ~ 3081
4. [학술지(정기간행물)] - Luo XD / 2000 / Limonoids and phytol derivatives from Cedrela sinensis / Fitoterapia : 492 ~ 496
5. [학술지(정기간행물)] - Park JC / 1994 / Studies on the chemical components and biological activities of edible plants in Korea / J Korean Soc Food Nutr : 116 ~ 119
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