지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.10
- 수록면
- 858 - 862 (5page)
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초록· 키워드
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The present study was conducted to examine the antioxidant activities and neuroprotective effects of methanolic extracts from Schizonepeta tenuifolia Briquet (STE). STE (100 μg/mL) showed 43.33 μM of total phenolic content, 64.43% of radical scavenging activity, and 0.157 of reducing power. In addition, the effect of STE on H₂O₂-induced DNA damage in human leucocytes was evaluated by the comet assay, where STE was a dose dependent inhibitor of DNA damage induced by 200 μM of H₂O₂. The protective effect of STE against H₂O₂-induced oxidative damage on PC12 cells was investigated by an 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) reduction assay and lactate dehydrogenase (LDH) release assays. After 2 hr of cell exposure to H₂O₂ (500 μM), a marked reduction in cell survival was observed. However, this reduction was significantly prevented by 1-50 μg/mL of STE. Therefore, these results suggest that STE could be a new antioxidant candidate against neuronal diseases.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References
참고문헌 (33)
참고문헌 신청
1. [학술지(정기간행물)] - / 1999 / Antioxidants, oxidative stress, and degenerativeneurological disorders 222 : 236 ~ 245
2. [학술지(정기간행물)] - / 1999 / Alzheimer’s disease and oxidative stress: Implications for novel therapeutic approaches 57 : 301 ~ 323
3. [학술지(정기간행물)] - / 1999 / Etiology and pathogenesis of Parkinson’sdisease 22 : 123 ~ 144
4. [학술지(정기간행물)] - / 2006 / Iptakalim protects PC 12cell against H2O2-induced oxidative injury via opening mitochondrial ATP-sensitive potassium channel 350 : 307 ~ 314
5. [학술지(정기간행물)] - / 2005 / Strawberry and its anthocyanins reduce oxidative stress-induced apoptosis in PC12 cells 53 : 1984 ~ 1989
2. [학술지(정기간행물)] - / 1999 / Alzheimer’s disease and oxidative stress: Implications for novel therapeutic approaches 57 : 301 ~ 323
3. [학술지(정기간행물)] - / 1999 / Etiology and pathogenesis of Parkinson’sdisease 22 : 123 ~ 144
4. [학술지(정기간행물)] - / 2006 / Iptakalim protects PC 12cell against H2O2-induced oxidative injury via opening mitochondrial ATP-sensitive potassium channel 350 : 307 ~ 314
5. [학술지(정기간행물)] - / 2005 / Strawberry and its anthocyanins reduce oxidative stress-induced apoptosis in PC12 cells 53 : 1984 ~ 1989
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UCI(KEPA) : I410-ECN-0101-2013-573-001011377