지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.3
- 수록면
- 16 - 24 (9page)
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Purpose: Reactivation of hepatitis B virus (HBV) replication after hepatic resection might be a significant risk factor for prognosis in patients with chronic hepatitis B. The purpose of the present study was to investigate the changing pattern of serum HBV DNA titer after hepatic resection and to assess the incidence of reactivation of HBV replication.
Methods: Among HBV-positive patients who underwent hepatic resection for hepatocellular carcinoma, thirty-six patients with preoperative serum HBV DNA titer ≥3 log10copies/mL were enrolled. Serum DNA titers were examined before the operation, on the second and seventh postoperative days, and one month after the operation.
Results: The serum DNA titer decreased on the second postoperative day (p=0.078). The DNA level, however, had substantially returned to preoperative values by the seventh postoperative day (p＜0.001). For most patients, the postoperative DNA titer reached its zenith on the seventh postoperative day or one month after the operation. The zenith level was higher (by 0.49±0.25 log10copies/mL) than preoperative levels although this difference just missed significance (p=0.068). Although postoperative reactivation of HBV replication emerged in 6 patients, only one of those patients developed postoperative hepatitis. Overall, four patients developed postoperative hepatitis and all of them had high postoperative HBV DNA levels (over 6 log10copies/mL).
Conclusion: Although serum HBV DNA titers tended to increase postoperatively, routine antiviral therapy might be unnecessary because of the low incidence of postoperative hepatitis. High postoperative DNA levels, however, might be a risk factor for hepatitis, and postoperative follow-up of serum HBV DNA levels might be necessary in HBV-positive patients with hepatic resection.
Methods: Among HBV-positive patients who underwent hepatic resection for hepatocellular carcinoma, thirty-six patients with preoperative serum HBV DNA titer ≥3 log10copies/mL were enrolled. Serum DNA titers were examined before the operation, on the second and seventh postoperative days, and one month after the operation.
Results: The serum DNA titer decreased on the second postoperative day (p=0.078). The DNA level, however, had substantially returned to preoperative values by the seventh postoperative day (p＜0.001). For most patients, the postoperative DNA titer reached its zenith on the seventh postoperative day or one month after the operation. The zenith level was higher (by 0.49±0.25 log10copies/mL) than preoperative levels although this difference just missed significance (p=0.068). Although postoperative reactivation of HBV replication emerged in 6 patients, only one of those patients developed postoperative hepatitis. Overall, four patients developed postoperative hepatitis and all of them had high postoperative HBV DNA levels (over 6 log10copies/mL).
Conclusion: Although serum HBV DNA titers tended to increase postoperatively, routine antiviral therapy might be unnecessary because of the low incidence of postoperative hepatitis. High postoperative DNA levels, however, might be a risk factor for hepatitis, and postoperative follow-up of serum HBV DNA levels might be necessary in HBV-positive patients with hepatic resection.
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참고문헌
참고문헌 (25)
참고문헌 신청
1. [단행본] - Ferlay J / 2004 / GLOBOCAN 2002: Cancer incidence, mortality, and prevalence worldwide. version 2.0 / IARC Press
2. [학술지(정기간행물)] - Bronowicki JP / 1996 / Comparison of resection, liver transplantation and transcatheter oily chemoembolization in the treatment of hepatocellular carcinoma / J Hepatol 24 : 293 ~ 300
3. [학술지(정기간행물)] - Curley SA / 2000 / Radiofrequency ablation of hepatocelluar carcinoma in 110 patients with cirrhosis / Ann Surg 232 : 381 ~ 391
4. [학술지(정기간행물)] - 최진섭 / 2005 / 다발성간세포암에 대한 간절제와 술중 고주파열치료 병합요법 / 한국간담췌외과학회지 9 (3) : 150 ~ 155
5. [학술지(정기간행물)] - Jee SH / 2004 / Cigarette smoking, alcohol drinking, hepatitis B virus, and risk for hepatocellular carcinoma in Korea / J Natl Cancer Inst 96 : 1851 ~ 1856
2. [학술지(정기간행물)] - Bronowicki JP / 1996 / Comparison of resection, liver transplantation and transcatheter oily chemoembolization in the treatment of hepatocellular carcinoma / J Hepatol 24 : 293 ~ 300
3. [학술지(정기간행물)] - Curley SA / 2000 / Radiofrequency ablation of hepatocelluar carcinoma in 110 patients with cirrhosis / Ann Surg 232 : 381 ~ 391
4. [학술지(정기간행물)] - 최진섭 / 2005 / 다발성간세포암에 대한 간절제와 술중 고주파열치료 병합요법 / 한국간담췌외과학회지 9 (3) : 150 ~ 155
5. [학술지(정기간행물)] - Jee SH / 2004 / Cigarette smoking, alcohol drinking, hepatitis B virus, and risk for hepatocellular carcinoma in Korea / J Natl Cancer Inst 96 : 1851 ~ 1856
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UCI(KEPA) : I410-ECN-0101-2014-514-001278148